A rare case of Histoplasma fungemia in an AIDS patient

Baradkar, V. P.; Tendolkar, U.; Baveja, S; Kamath, S.
April 2011
Indian Journal of Medical Microbiology;Apr2011, Vol. 29 Issue 2, p188
Academic Journal
Case Study
Disseminated cases of histoplasmosis in acquired immune deficiency syndrome (AIDS) are rarely reported from India. Most of these cases report isolation of this fungus from the bone marrow, lymph node aspirate, spleenic aspirate, and biopsies. We report isolation of Histoplasma capsulatum from the blood of an AIDS patient. A 30-year-old male from Utter Pradesh was admitted with fever, loss of appetite, and nausea since two months. Few intracellular and extracellular budding cells were observed on bone marrow examination on the fifth day of admission. Diagnosis was confirmed by blood cultures taken on the 11th day of admission. Amphotericin B was started, but the patient's condition deteriorated and he died.


Related Articles

  • Preventing fungal infection in neutropenic patients with acute leukemia: fluconazole compared with oral amphotericin B. Menichetti, Francisco; Favero, Albano Del; Martino, Piero; Bucaneve, Giampolo; Micozzi, Alessandra; D'Antonio, Domenico; Ricci, Paolo; Carotenuto, Mario; Liso, Vincenzo; Nosari, Anna Maria; Barbui, Tiziano; Fasola, Giampiero; Mandelli, Franco; Menichetti, F; Del Favero, A; Martino, P; Bucaneve, G; Micozzi, A; D'Antonio, D; Ricci, P // Annals of Internal Medicine;6/1/94, Vol. 120 Issue 11, p913 

    Objective: To compare the efficacy and tolerability of fluconazole and oral amphotericin B in preventing fungal infection in neutropenic patients with acute leukemia.Design: A randomized, controlled, multicenter trial.Setting: 30 hematologic units in...

  • Fungal colonization in neutropenic patients: a randomized study comparing itraconazole solution and amphotericin B solution. Lass-Flörl, C.; Gunsilius, E.; Gastl, G.; Englisch, M.; Koch, G.; Ulmer, H.; Dierich, M. P.; Petzer, A. // Annals of Hematology;Sep2003, Vol. 82 Issue 9, p565 

    We assessed the impact of prophylaxis with the oral itraconazole solution and amphotericin B solution on fungal colonization and infection in a randomized study among patients with hematological malignancies and neutropenia. Infecting and colonizing Candida strains of patients suffering from...

  • Prophylaxis of invasive fungal infections in patients with hematological malignancies and solid tumors: Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO). Cornely, Oliver A.; Böhme, Angelika; Buchheidt, Dieter; Glasmacher, Axel; Kahl, Christoph; Karthaus, Meinolf; Kern, Winfried; Krüger, William; Maschmeyer, Georg; Ritter, Jörg; Salwender, Hans J.; Sandherr, Michael; Schiel, Xaver; Schüttrumpf, Silke; Sieniawski, Michal; Silling, Gerda; Ullmann, Andrew J.; Wolf, Hans-Heinrich // Annals of Hematology;Oct2003 Supplement 2, Vol. 82, pS186 

    Morbidity and mortality in patients with malignancies, especially leukemia and lymphoma, are increased by invasive fungal infections. Since diagnosis of invasive fungal infection is often delayed, antifungal prophylaxis is an attractive approach for patients expecting prolonged neutropenia....

  • Amphotericin B liposomal.  // Reactions Weekly;1/26/2008, Issue 1186, p8 

    The article describes the case of four patients who developed hyperphosphataemia during treatment with amphotericin B liposomal for invasive mycoses. An 11-year-old boy, who had Aspergillosis fumigatis, received amphotericin B liposomal and developed hyperphosphataemia, which led to drug...

  • Experimental Pulmonary Aspergillosis Due to Aspergillus terreus: Pathogenesis and Treatment of an Emerging Fungal Pathogen Resistant to Amphotericin B. Walsh, Thomas J.; Petraitis, Vidmantas; Petraitiene, Ruta; Field-Ridley, Aida; Sutton, Deanna; Ghannoum, Mahmoud; Sein, Tin; Schaufele, robert; Peter, Joanne; Bacher, John; Casler, Heather; Armstrong, derek; Espinel-Ingroff, Anna; Rinaldi, Michael G.; Lyman, Caronh A. // Journal of Infectious Diseases;7/15/2003, Vol. 188 Issue 2, p305 

    Aspergillus terreus is an uncommon but emerging fungal pathogen, which causes lethal infections that are often refractory to amphotericin B (AmB). In comparison to Aspergillus fumigatus, A. terreus was resistant to the in vitro fungicidal effects of safely achievable concentrations of AmB. These...

  • FORMULATION, DEVELOPMENT AND EVALUATION OF TRANSFERSOMAL GEL OF AMPHOTERICIN B. Verma, Neelam; Jain, Shailesh; Gupta, Naveen; Kapoor, Vishal; Rajput, Dharmendra // Journal of Advanced Scientific Research;2019 suplement 2, Vol. 10 Issue 4, p254 

    Fungal infections are amongst the most commonly encountered diseases affecting the skin. Treatment approaches include both topical and oral antifungal agents. The topical route is generally preferred due to the possible side effects of oral medication. Advances in the field of formulation may...

  • Voriconazole Treatment of Disseminated Paecilomyces Infection in a Patient with Acquired Immunodeficiency Syndrome. Martin, Craig A.; Roberts, Sara; Greenberg, Richard N. // Clinical Infectious Diseases;10/1/2002, Vol. 35 Issue 7, p78 

    Discusses the case of a 40-year-old male patient presenting with disseminated Paecilomyces lilacinus infection with acquired immunodeficiency syndrome. Risk factors; Failed treatment using oral itraconazole, amphoterecin B and amphoterecin B lipid complex; Improvement of condition with...

  • Central Nervous System Paracoccidioidomycosis in an AIDS Patient: Case Report. Silva-Vergara, Mario; Rocha, Ivonete; Vasconcelos, Rakel; Maltos, André; Freitas Neves, Fernando; Almeida Silva Teixeira, Luciana; Mora, Delio // Mycopathologia;Feb2014, Vol. 177 Issue 1/2, p137 

    Up to now, over 200 patients with paracoccidioidomycosis (PCM) associated to HIV infection have already been reported; however, the central nervous system involvement in this coinfection was rarely reported. This paper presents a 35-year-old Brazilian male AIDS patient who developed pulmonary...

  • Amphotericin B Lipid Complex in the Treatment of Invasive Fungal Infections: Results of the Collaborative Exchange of Antifungal Research (CLEAR), an Industry-Supported Patient Registry. Pappas, Peter G. // Clinical Infectious Diseases;5/1/2005 Supplement, Vol. 40, pS379 

    This article focuses on the use of amphotericin B lipid complex (ABLC) for the treatment of invasive fungal infections. ABLC is a composition of amphotericin B and 2 phospholipids, dimyristoylphosphatidylcholine and dimyristoylphosphatidylglycerol, in a 1:1 drug-to-lipid molar ratio. ABLC was...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics