Is the association between optimistic cardiovascular risk perceptions and lower rates of cardiovascular disease mortality explained by biomarkers of systemic inflammation or endothelial function? A case-cohort study

Gramling, Robert; Heffner, Kathi L.; Klein, William M. P.; Zajac, Laura E.; Roberts, Mary; Eaton, Charles B.
January 2010
BioPsychoSocial Medicine;2010, Vol. 4, p11
Academic Journal
Case Study
Background: More optimistic perceptions of cardiovascular disease risk are associated with substantively lower rates of cardiovascular death among men. It remains unknown whether this association represents causality (i.e. perception leads to actions/conditions that influence cardiovascular disease occurrence) or residual confounding by unmeasured factors that associate with risk perceptions and with physiological processes that promote cardiovascular disease (i.e. inflammation or endothelial dysfunction). Purpose: To evaluate whether previously unmeasured biological markers of inflammation or endothelial dysregulation confound the observed association between cardiovascular disease risk perceptions and cardiovascular disease outcomes; Methods: We conducted a nested case-cohort study among community-dwelling men from Southeastern New England (USA) who were interviewed between 1989 and 1990 as part of the Pawtucket Heart Health Program. We measured C-reactive protein (CRP) and Vascular Endothelial Growth Factor (VEGF) levels from stored sera for a random sample of the parent cohort (control sample, n = 127) and all cases of cardiovascular death observed through 2005 (case sample, n = 44). We evaluated potential confounding using stratified analyses and logistic regression modeling. Results: Optimistic ratings of risk associated with lower odds of dying from cardiovascular causes among men (OR = 0.39, 95% CI = 0.17, 0.91). Neither CRP nor VEGF confounded these findings. Conclusions: The strong cardio-protective association between optimistic ratings of cardiovascular disease risk and lower rates of cardiovascular mortality among men is not confounded by baseline biomarkers of systemic inflammation or endothelial dysfunction.


Related Articles

  • NT-proBNP Linking Low-Moderately Impaired Renal Function and Cardiovascular Mortality in Diabetic Patients: The Population-Based Casale Monferrato Study. Bruno, Graziella; Barutta, Federica; Landi, Andrea; Cavallo Perin, Paolo; Gruden, Gabriella // PLoS ONE;Dec2014, Vol. 9 Issue 12, p1 

    Background: Few data are available to assess whether a low-moderate reduction in estimated glomerular filtration rates (eGFR) has a role per se on cardiovascular (CV) mortality or other biomarkers such as NT-proBNP allow to explain such association. Methods and Findings: In a prospective study...

  • The Association of Uremic Toxins and Inflammation in Hemodialysis Patients. Hsu, Heng-Jung; Yen, Chiung-Hui; Wu, I-Wen; Hsu, Kuang-Hung; Chen, Chih-Ken; Sun, Chiao-Yin; Chou, Chia-Chi; Chen, Chun-Yu; Tsai, Chi-Jen; Wu, Mai-Szu; Lee, Chin-Chan // PLoS ONE;Jul2014, Vol. 9 Issue 7, p1 

    Background: Cardiovascular disease is the leading cause of mortality in hemodialysis patients and is associated with chronic inflammation. Elevation of uremic toxins, particular protein-bound uremic toxins, is a possible cause of hyper-inflammation in hemodialysis patients. But the association...

  • Insulin Resistance, Cystatin C, and Mortality Among Older Adults. De Boer, Ian H.; Katz, Ronit; Chonchol, Michel B.; Fried, Linda F.; Kestenbaum, Bryan; Mukamal, Kenneth J.; Peralta, Carmen A.; Siscovick, David S. // Diabetes Care;Jun2012, Vol. 35 Issue 6, p1355 

    OBJECTIVE - Insulin resistance is a risk factor for cardiovascular and noncardiovascular diseases. Impaired kidney function is linked with insulin resistance and may affect relationships of insulin resistance with health outcomes. RESEARCH DESIGN AND METHODS - We performed a cohort study of...

  • N-Terminal Probrain Natriuretic Peptide Is a Stronger Predictor of Cardiovascular Mortality Than C-Reactive Protein and Albumin Excretion Rate in Elderly Patients With Type 2 Diabetes. BRUNO, GRAZIELLA; LANDI, ANDREA; BARUTTA, FEDERICA; GHEZZO, GIUSEPPE; BALDIN, CLAUDIO; SPADAFORA, LAURA; SCHIMMENTI, ANDREA; PRINZIS, TANIA; PERIN, PAOLO CAVALLO; GRUDEN, GABRIELLA // Diabetes Care;Sep2013, Vol. 36 Issue 9, p2677 

    OBJECTIVE--To study whether N-terminal probrain natriuretic peptide (NT-proBNP) is a short-term independent predictor of both all-cause and cardiovascular (CV) mortality in type 2 diabetic patients and to establish whether albuminuria and C-reactive protein (CRP) affect this relationship....

  • GDF-15 for Prognostication of Cardiovascular and Cancer Morbidity and Mortality in Men. Wallentin, Lars; Zethelius, Bj√∂rn; Berglund, Lars; Eggers, Kai M.; Lind, Lars; Lindahl, Bertil; Wollert, Kai C.; Siegbahn, Agneta // PLoS ONE;Dec2013, Vol. 8 Issue 12, p1 

    The objective was to evaluate the hypothesis that growth-differentiation factor 15 (GDF-15) is an independent marker of the long-term risk for both cardiovascular disease and cancer morbidity beyond clinical and biochemical risk factors. Plasma obtained at age 71 was available from 940 subjects...

  • Postprandial Oxidative Stress and Gastrointestinal Hormones: Is There a Link? Malinska, Hana; Kahleova, Hana; Topolcan, Ondrej; Vrzalova, Jindra; Oliyarnyk, Olena; Kazdova, Ludmila; Belinova, Lenka; Hill, Martin; Pelikanova, Terezie // PLoS ONE;Aug2014, Vol. 9 Issue 8, p1 

    Background: Abnormal postprandial elevation of plasma glucose and lipids plays an important role in the pathogenesis of diabetes and strongly predicts cardiovascular mortality. In patients suffering from type 2 diabetes (T2D) postprandial state is associated with oxidative stress, cardiovascular...

  • NT-proBNP Best Predictor of Cardiovascular Events and Cardiovascular Mortality in Secondary Prevention in Very Old Age: The Leiden 85-Plus Study. van Peet, Petra G.; Drewes, Yvonne M.; de Craen, Anton J. M.; Gussekloo, Jacobijn; de Ruijter, Wouter // PLoS ONE;Nov2013, Vol. 8 Issue 11, p1 

    Background:In the aging population cardiovascular disease (CVD) is highly prevalent. Identification of very old persons at high risk of recurrent CVD is difficult, since traditional risk markers loose predictive value with age. Methods:In a population-based sample of 282 85-year old...

  • A Module of Human Peripheral Blood Mononuclear Cell Transcriptional Network Containing Primitive and Differentiation Markers Is Related to Specific Cardiovascular Health Variables. Moldovan, Leni; Anghelina, Mirela; Kantor, Taylor; Jones, Desiree; Ramadan, Enass; Xiang, Yang; Huang, Kun; Kolipaka, Arunark; Malarkey, William; Ghasemzadeh, Nima; Mohler, Peter J.; Quyyumi, Arshed; Moldovan, Nicanor I. // PLoS ONE;Apr2014, Vol. 9 Issue 4, p1 

    Peripheral blood mononuclear cells (PBMCs), including rare circulating stem and progenitor cells (CSPCs), have important yet poorly understood roles in the maintenance and repair of blood vessels and perfused organs. Our hypothesis was that the identities and functions of CSPCs in cardiovascular...

  • Multimarker Proteomic Profiling for the Prediction of Cardiovascular Mortality in Patients with Chronic Heart Failure. Lemesle, Gilles; Maury, Fleur; Beseme, Olivia; Ovart, Lionel; Amouyel, Philippe; Lamblin, Nicolas; de Groote, Pascal; Bauters, Christophe; Pinet, Florence // PLoS ONE;Apr2015, Vol. 10 Issue 4, p1 

    Risk stratification of patients with systolic chronic heart failure (HF) is critical to better identify those who may benefit from invasive therapeutic strategies such as cardiac transplantation. Proteomics has been used to provide prognostic information in various diseases. Our aim was to...

  • The Clinical Performance of an Office-Based Risk Scoring System for Fatal Cardiovascular Diseases in North-East of Iran. Sepanlou, Sadaf G.; Malekzadeh, Reza; Poustchi, Hossein; Sharafkhah, Maryam; Ghodsi, Saeed; Malekzadeh, Fatemeh; Etemadi, Arash; Pourshams, Akram; Pharoah, Paul D.; Abnet, Christian C.; Brennan, Paul; Boffetta, Paolo; Dawsey, Sanford M.; Kamangar, Farin // PLoS ONE;May2015, Vol. 10 Issue 5, p1 

    Background: Cardiovascular diseases (CVD) are becoming major causes of death in developing countries. Risk scoring systems for CVD are needed to prioritize allocation of limited resources. Most of these risk score algorithms have been based on a long array of risk factors including blood...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics