Acetylcholinesterase Inhibitors (AChEI's) for the treatment of visual hallucinations in schizophrenia: a case report

Patel, Sachin S.; Attard, Azizah; Jacobsen, Pamela; Shergill, Sukhi
January 2010
BMC Psychiatry;2010, Vol. 10, p68
Academic Journal
Case Study
Background: Visual hallucinations are commonly seen in various neurological and psychiatric disorders including schizophrenia. Current models of visual processing and studies in diseases including Parkinsons Disease and Lewy Body Dementia propose that Acetylcholine (Ach) plays a pivotal role in our ability to accurately interpret visual stimuli. Depletion of Ach is thought to be associated with visual hallucination generation. AchEI's have been used in the targeted treatment of visual hallucinations in dementia and Parkinson's Disease patients. In Schizophrenia, it is thought that a similar Ach depletion leads to visual hallucinations and may provide a target for drug treatment Case Presentation: We present a case of a patient with Schizophrenia presenting with treatment resistant and significantly distressing visual hallucinations. After optimising treatment for schizophrenia we used Rivastigmine, an AchEI, as an adjunct to treat her symptoms successfully. Conclusions: This case is the first to illustrate this novel use of an AchEI in the targeted treatment of visual hallucinations in a patient with Schizophrenia. Targeted therapy of this kind can be considered in challenging cases although more evidence is required in this field.


Related Articles

  • Acetylcholinesterase Inhibitors (AChEI's) for the treatment of visual hallucinations in schizophrenia: A review of the literature. Patel, Sachin S.; Attard, Azizah; Jacobsen, Pamela; Shergill, Sukhi // BMC Psychiatry;2010, Vol. 10, p69 

    Background: Visual hallucinations occur in various neurological diseases, but are most prominent in Lewy body dementia, Parkinson's disease and schizophrenia. The lifetime prevalence of visual hallucinations in patients with schizophrenia is much more common than conventionally thought and...

  • Talking therapy trialled for command hallucinations. McMillan, Ian // Mental Health Practice;Feb2012, Vol. 15 Issue 5, p6 

    The article discusses research being done on cognitive behavior approaches as treatment for command hallucinations. It references the study "A Multi-Centre, Randomized Controlled Trial of Cognitive Therapy to Prevent Harmful Compliance With Command Hallucinations," by M Birchwood and colleagues...

  • Schizophrenia and Other Psychotic Disorders. de Beaurepaire, Renaud; Honig, Adriaan; Blass, John // Current Medical Literature: Psychiatry;2012, Vol. 23 Issue 3, p81 

    The article discusses studies on schizophrenia and other psychotic disorders, published in medical journals as of 2012. One study examined transcranial direct-current stimulation (tDCS) as a treatment method for hallucinations in schizophrenia. Another discussed metformin as a treatment of...

  • Hallucinations in schizophrenia. White, Adrian // Acupuncture in Medicine;Sep2010, Vol. 28 Issue 3, p156 

    The article presents a summary and commentary on the use of electro-acupuncture to treat auditory hallucinations in schizophrenic patients.

  • Schizophrenics Are People. Allen, John S. // Humanist;May/Jun91, Vol. 51 Issue 3, p26 

    Argues that schizophrenics have been wrongfully dehumanized. Deinstitutionalization has put them on the streets; Lack of advocacy groups; A special disease which needs to be examined in a more human, less clinical way.

  • Versión abreviada del WAIS-III para su uso en la evaluación de pacientes con diagnóstico de esquizofrenia. Durá, Inmaculada Fuentes; Pens, Maria Romero; Vivó, Carmen Dasí; Ruiz, Juan Carlos Ruiz // Psicothema; 

    The aim of this study is to obtain a sufficiently guaranteed, abridged, Spanish version of the WAIS-III and thereby reduce the time needed to administer the complete scale. Although the samples used were based both on normal individuals (41 participants with no known history of mental illness)...

  • Validation in mental health treatment. McLean, Richard // Australian Nursing Journal;Dec2009/Jan2010, Vol. 17 Issue 6, p33 

    The author ponders on the provision of mental health services to people with schizophrenia in Australia. He describes how schizophrenics cope with their mental illness. He proposes an approach that psychiatrists should consider when dealing with their schizophrenic patients. The author opines...

  • PAPEL DE LA EXPERIENCE EN LA ACEPTACIÓN VS. RECHAZO DEL PACIENTE CON ESQUIZOFRENIA. Senra-Rivera, Carmen; de Arriba-Rossetto, Alessandra; Seoane-Pesqueira, Gloria // Revista Latinoamericana de Psicología;2008, Vol. 40 Issue 1, p73 

    This research analyzes the influence of different types and degrees of experience with mental illness regarding acceptance vs. rejection of mental disorders and of the patient with schizophrenia. 236 university students were involved in the study by filling a social distance scale related with a...

  • Küuver-Bucy Syndrome and Psychiatric Illness. Clarke, D. J.; Brown, N. S. // British Journal of Psychiatry;Sep90, Vol. 157, p439 

    A 52-year-old woman, whose initial psychiatric presentation at the age of 15 was with a disorder resembling schizophrenia, developed symptoms of Klüver-Bucy syndrome, and is now thought to suffer from an organic psychotic disorder. Klüver-Bucy syndrome must be distinguished from symptoms...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics