TITLE

Hypertension after Clonidine Withdrawal

AUTHOR(S)
Scandura, Casey J.
PUB. DATE
August 2010
SOURCE
International Student Journal of Nurse Anesthesia;Summer2010, Vol. 9 Issue 2, p11
SOURCE TYPE
Academic Journal
DOC. TYPE
Case Study
ABSTRACT
Clonidine is a centrally acting selective alpha 2 adrenergic agonist. Clonidine can reduce anesthetic requirements, improve perioperative hemodynamic stability, provide sedation, and modulate pain pathways resulting in analgesia. It has the ability to attenuate sympathetic nervous system output by a negative feedback mechanism at the alpha 2 receptor site. This drug has proven to be particularly effective in treating severe hypertension or renindependent hypertensive disease. Abrupt discontinuation of clonidine therapy can result in a phenomenon labeled rebound hypertension. This increase in systemic blood pressure may be associated with an increase in circulating catecholamines and intense vasoconstriction.
ACCESSION #
53170889

 

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