TITLE

Maternal Folate and Vitamin B12 Status and Neural Tube Defects in Northern Iran: A Case Control Study

AUTHOR(S)
Mobasheri, Elahm; Keshtkar, Abbasali; Golalipour, Mohammad-Jafar
PUB. DATE
June 2010
SOURCE
Iranian Journal of Pediatrics;Jun2010, Vol. 20 Issue 2, p167
SOURCE TYPE
Academic Journal
DOC. TYPE
Case Study
ABSTRACT
Objective: This study was conducted to determine the serum level of folic acid and vitamin B12 in neural tube defects pregnancies (NTD) and healthy controls in Northern Iran. Methods: This case-control study was performed on women with neural tube defects pregnancies and controls with unaffected pregnancies in Northern Iran during 2006. Twenty three pregnant women whose pregnancies were diagnosed as NTD by a second-trimester ultrasonographic examination were recruited as cases. The control group (n=23) consisted of women who were selected among socio-economic status (SES) matched women who had a normal targeted ultrasound during the second trimester with documented normal fet al outcome. Fetal NTD was suspected with targeted second-trimester ultrasound during the 16th week of gestation and confirmed with high maternal serum α-fetoprotein levels. Folate, vitamin B12, homocysteine and alpha fetoprotein were evaluated after target ultrasonography. Findings: Serum alpha fetoprotein level (mean ± SD) in cases and controls was 120.2±64.1 and 50±33.5 iu/ml, respectively (P<0.05). The mean ± SD folate in cases and controls was 8.4±4.2 versus 9.3±4.2 ng/ml, respectively. This difference was not significant. Folate deficiency was found in 30.4% of the cases and 13% of the controls (OR = 2.9, 95%: 0.54-19.8). Vitamin B12 deficiency was found in 13 % of cases and 17.7% of the controls (OR=0.7, 95%: 0.1-4.9). Conclusion: This study showed that the probability of having a newborn with NTDs in maternal folate deficiency is three times higher than with normal folate in Northern Iran.
ACCESSION #
52527611

 

Related Articles

  • Epidemiology of neural tube defects and folic acid. Shurtleff, D. // Cerebrospinal Fluid Research;2004 Supplement 1, Vol. 1, p1 

    The article considers the role played by folic acid in diminishing the occurrence of neural tube defects. According to the author, studies demonstrate the effects of intrauterine diagnosis and selective termination prior to fortification of foodstuffs with folic acid. The author adds that since...

  • Orange juice is a good folate source in respect to folate content and stability during storage and simulated digestion. Öhrvik, Veronica; Witthöft, Cornelia // European Journal of Nutrition;Mar2008, Vol. 47 Issue 2, p92 

    Estimated average folate intake in Sweden is less than 55% of the recommended daily intake (RDI) for women of childbearing age (Becker and Pearson in Riksmaten 1997–1998 Kostvanor och näringsintag i Sverige. National Food Administration, Uppsala, pp 34, 44, 121, 2002). Because a good...

  • Lack of Association between Folate-Receptor Autoantibodies and Neural-Tube Defects. Molloy, Anne M.; Quadros, Edward V.; Sequeira, Jeffrey M.; Troendle, James F.; Scott, John M.; Kirke, Peadar N.; Mills, James L. // New England Journal of Medicine;7/9/2009, Vol. 361 Issue 2, p152 

    Background: A previous report described the presence of autoantibodies against folate receptors in 75% of serum samples from women with a history of pregnancy complicated by a neural-tube defect, as compared with 10% of controls. We sought to confirm this finding in an Irish population, which...

  • Research goals for folate and related B vitamin in Europe. Finglas, P. M.; de Meer, K.; Molloy, A.; Verhoef, P.; Pietrzik, K.; Powers, H. J.; van der Straeten, D.; J.ägerstad, M.; Varela-Moreiras, G.; van Vliet, T.; Havenaar, R.; Buttriss, J.; Wright, A. J. A. // European Journal of Clinical Nutrition;Feb2006, Vol. 60 Issue 2, p287 

    In the past decade, the understanding of folate bioavailability, metabolism and related health issues has increased, but several problems remain, including the difficulty of delivering the available knowledge to the populations at risk. Owing to the low compliance of taking folic acid...

  • Folic acid to reduce neonatal mortality from neural tube disorders. Blencowe, Hannah; Cousens, Simon; Modell, Bernadette; Lawn, Joy // International Journal of Epidemiology;Apr2010 Supplement 1, Vol. 39 Issue suppl_1, pi110 

    Background Neural tube defects (NTDs) remain an important, preventable cause of mortality and morbidity. High-income countries have reported large reductions in NTDs associated with folic acid supplementation or fortification. The burden of NTDs in low-income countries and the effectiveness of...

  • Folate in food. Bellingan, Laura // Biologist;May2007, Vol. 54 Issue 2, p63 

    The article reports on the move of the Institute of Biology to increase the folate intake of young women in Great Britain. Such move answers the consultation by the Food Standards Agency (FSA), as it has found out that a lot of people lacks folate intake, which is believed to affect fetal...

  • Prevalence and predictors of periconceptional folic acid uptake—prospective cohort study in an Irish urban obstetric population. McGuire, M.; Cleary, B.; Sahm, L.; Murphy, D. J. // Human Reproduction;Feb2010, Vol. 25 Issue 2, p535 

    BACKGROUND: Neural tube defects (NTDs) are severe abnormalities of the central nervous system that occur as a result of abnormal development in the third and fourth weeks of gestation. Studies have shown that periconceptional folic acid (FA) can reduce both the incidence and recurrence of NTDs.

  • Folsäuresubstitution bei Frauen mit Epilepsie. Bauer, J.; Bös, M.; Rück, J.; Stoffel-Wagner, B. // Der Nervenarzt;Apr2011, Vol. 82 Issue 4, p459 

    Insufficient maternal folate concentrations appear to be a fetal risk factor for neural tube defects (NTD). Erythrocyte folate concentrations are widely accepted as an indicator of tissue folate storage. We retrospectively evaluated erythrocyte folate concentrations to examine if a recommended...

  • Folic acid fortified milk increases red blood cell folate concentration in women of childbearing age. Rockell, J. E. P.; Venn, B. J.; Skeaff, C. M.; Green, T. J. // Asia Pacific Journal of Clinical Nutrition;2004 Supplement, Vol. 13, pS84 

    Background - Folic acid (~400 µg/day) taken around the time of conception significantly reduces the risk of bearing a child with a neural tube defect (NTD). Strategies to reduce NTDs with folic acid include supplement use and fortified foods. One fortification option is to add folic acid to...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics