TITLE

Centeromeric breakage and fragile site expression in cryptorchidism - A case report

AUTHOR(S)
Saxena, Ajit Kumar; Singh, Divya; Singh, Gajendra
PUB. DATE
January 2010
SOURCE
Current Pediatric Research;Jan2010, Vol. 14 Issue 1, p25
SOURCE TYPE
Academic Journal
DOC. TYPE
Case Study
ABSTRACT
The present case was phenotypically male except that testes were not present in the scrotum. Hence in this case of "cryptorchidism", the genetic study becomes imperative for thorough analysis. Chromosomal study revealed more than 13.3 % centromeric breaks per cell in metaphase . The high incidence (3.6%) of common fragile sites ex-pression (7q11, 2q21, 3p14) were also noticed after addition of 5-azacytidine. These "genetic factors" might influence the weight of the testis or alter hormonal level which is essential for normal growth and descent of testis in mammals.
ACCESSION #
51892686

 

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