Centeromeric breakage and fragile site expression in cryptorchidism - A case report

Saxena, Ajit Kumar; Singh, Divya; Singh, Gajendra
January 2010
Current Pediatric Research;Jan2010, Vol. 14 Issue 1, p25
Academic Journal
Case Study
The present case was phenotypically male except that testes were not present in the scrotum. Hence in this case of "cryptorchidism", the genetic study becomes imperative for thorough analysis. Chromosomal study revealed more than 13.3 % centromeric breaks per cell in metaphase . The high incidence (3.6%) of common fragile sites ex-pression (7q11, 2q21, 3p14) were also noticed after addition of 5-azacytidine. These "genetic factors" might influence the weight of the testis or alter hormonal level which is essential for normal growth and descent of testis in mammals.


Related Articles

  • cryptorchid, cryptorchis.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p552 

    A definition of the medical term "cryptorchid or cryptorchis," which refers to an individual in whom either or both testicles have not descended into the scrotum, is presented.

  • cryptorchidism, cryptorchism.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p553 

    A definition of the medical term "cryptorchidism or cryptorchism," which refers to the failure of the testicles to descend into the scrotum, is presented.

  • INSL3/LGR8 role in testicular descent and cryptorchidism. Bogatcheva, Natalia V.; Agoulnik, Al // Reproductive BioMedicine Online (Reproductive Healthcare Limited;Jan2005, Vol. 10 Issue 1, p49 

    Cryptorchidism, generally referred lo a failure of testicular descent into the scrotum, is the most frequent (up to 3-4% at birth) congenital anomaly in newborn boys. Cryptorchidism is closely associated with impaired fertility, and represents an established risk factor for testicular cancer....

  • cryptorchidism. Peters, Michael // BMA A-Z Family Medical Encyclopedia;2004, p206 

    A definition of the term "cryptorchidism" is presented. It refers to a developmental disorder of male infants in which the testes fail to descend normally into the scrotum.

  • Laparoscopic Stephen-Fowler Stage Procedure: Appropriate Management for High Intra-Abdominal Testes. Agrawal, Amit; Joshi, Milind; Mishra, Pankaj; Gupta, Rahul; Sanghvi, Beejal; Parelkar, Sandesh // Journal of Laparoendoscopic & Advanced Surgical Techniques;Mar2010, Vol. 20 Issue 2, p183 

    The length of testicular vessels is the main length-limiting factor to bring down the testes in the scrotum. Fowler and Stephen proposed the division of testicular vessels, high and as far from the testes as possible to maintain collateral blood supply, to treat high intra-abdominal testes....

  • Undescended Testicles. Anderson, Bradley // Pediatrics for Parents;May/Jun2012, Vol. 28 Issue 5/6, p16 

    The article offers the author's view regarding undescended testis in boys which he said is one of the most prevalent urologic conditions in boys. It notes that a surgery should be performed when undescended testis is discovered no matter how old a child is. Several reasons on why surgery for...

  • Abordul laparoscopic pentru testicule nepalpabile: aspecte tehnice si rezultate. Stanca, D.V.; Prundus, P.; Boc, A.; Manescu, R. M.; Bonat, S.; Coman, I. // Romanian Journal of Urology;Jun2011, Vol. 10 Issue 2, p22 

    Introduction and Objectives The diagnostic and terapeutic options for the cryptorchid testicles that are located in the abdominal cavity are limited. The laparoscopic approach is the only mini-invasive method that allows the localization of the testicles and the orchidopexy. The aim of this...

  • Bianchi high scrotal approach revisited. Samuel, David G.; Izzidien, Asal Y. // Pediatric Surgery International;Jun2008, Vol. 24 Issue 6, p741 

    Cryptorchidism is a common paediatric complaint and is traditionally managed surgically by orchidopexy. We aimed to prospectively review the success of the Bianchi high scrotal incision technique for performing orchidopexy in boys with palpable non-descended testis. A total of 206 orchidopexies...

  • Sperm output from unilateral cryptorchid Sahel goats. Igbokwe, I.; Abba, Y.; Geidam, S.; Igbokwe, N. // Comparative Clinical Pathology;Jul2014, Vol. 23 Issue 4, p819 

    Fertility of unilateral cryptorchid Sahel buck in uncontrolled breeding depends on sperm output of the scrotal testis. Semen evaluation and testicular and epididymal sperm head counts of cryptorchid and normal bucks were carried out at comparable age, body weight and testicular size. Mean semen...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics