Prevention of severe cutaneous adverse drug reactions: the emerging value of pharmacogenetic screening

Fernando, Suran L.; Broadfoot, Andrew J.
March 2010
CMAJ: Canadian Medical Association Journal;3/23/2010, Vol. 182 Issue 5, p476
Academic Journal
Case Study
The article presents a case study of a 35-year-old man who was taken to the emergency department after two weeks of therapy with allopurinol with fever, rash and mouth pain. It mentions that after two weeks of therapy, the oral mucositis and uretheritis of the patient was completely resolved. However, the patient still had corneal ulceration and is visually impaired after 18 months of therapy. It analyzes the genetic screening value in identifying the risk of patients to severe drug reactions.


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