Fetal Hydantoin Syndrome: A Case Report

Shakya, N. S.; Gurubacharya, S. M.; Aryal, D. R.
January 2010
Journal of Nepal Paediatric Society;2010, Vol. 30 Issue 1, p57
Academic Journal
Case Study
A term baby born to an epileptic mother who was treated with Phenytoin until 10weeks of pregnancy was born with multiple congenital anomalies and diagnosed to have Fetal Hydantoin Syndrome. Infants of mothers who have taken hydantoin during pregnancy have been found to have broad multisystem patterns of abnormalities, including mental retardation, craniofacial anomalies, nail and digital hypoplasia and prenatal onset of growth deficiency. The discussion aims to bring to attention the potential hazard of the use of hydantoin drug during reproductive age to all medical practitioners.


Related Articles

  • TREACHER COLLINS SYNDROME: CASE REPORT AND REVIEW OF LITERATURE. Kotha, Ravichandra Sekhar; Vijaya Prasad, K. E.; Vasa, Aron Arun Kumar; Sahana, Suzan // Annals & Essences of Dentistry;Oct-Dec2010, Vol. 2 Issue 4, p41 

    Treacher-Collins syndrome (TCS) is a rare congenital, craniofacial disorder that is inherited as an autosomal dominant pattern. The present case report describes TCS in a Caucasian girl aged 8 years with full tetrad of cardinal features in addition to mental retardation, deafness and dumbness...

  • MENTAL RETARDATION WITH COMPLEX PARTIAL SEIZURE IN A CASE OF CROUZON SYNDROME. Bhadu, Amit; Amin, Naren; Shah, Chetan; Mehta, Prakash; Patel, Kamlesh; Choudhary, Prema Ram // Journal of Pakistan Psychiatric Society;Jan-Jun2013, Vol. 10 Issue 1, p53 

    Crouzon's syndrome is a rare autosomal dominant skeletal disorder caused by multiple mutations in the fibroblast growth factor receptor 2 (FGFR2) gene. Two genes are known to be associated with Crouzon syndrome, FGFR2 and FGFR3. FGFR stands for fibroblast growth factor receptor. These genes are...

  • Crouzon's syndrome: A review of literature and case report. Padmanabhan, Vivek; M. Hegde, Amitha; Rai, Kavita // Contemporary Clinical Dentistry;Jul-Sep2011, Vol. 2 Issue 3, p211 

    Crouzon's syndrome is an autosomal dominant disorder with complete penetrance and variable expressivity. Described by a French neurosurgeon in 1912, it is a rare genetic disorder. Crouzon's syndrome is caused by mutation in the fibroblast growth factor receptor 2 (FGFR2) gene. Normally, the...

  • Etiological heterogeneity of trigonocephaly: a retrospective study.  // Journal of Medical Genetics;Sep2007 Supplement 1, Vol. 44, pS54 

    An abstract of the study "Etiological heterogeneity of trigonocephaly: a retrospective study," by Usha Kini, J. Byren, A. Wilkie and J. Hurst is presented.

  • Premature Craniosynostosis in a Rare Genetic Disease- A Case Report. DHARAMSHI, Hasnain abbas; RAZA, Tufail; MOHSIN ALI, Ali Abbas; LILANI, Zuhair; AHSAN, Syed Zohaib; FARAZ, Ahmad; NAQVI, Syeda Tahira // Iranian Journal of Public Health;Mar2015, Vol. 44 Issue 3, p404 

    Background: Crouzon syndrome is a rare genetic disorder inherited in autosomal dominant pattern with complete penetration and variable expressivity.Its most notable characteristic feature is premature synostosis of cranial sutures The case presented is of a 4 yr old boy with box like head with...

  • Hydantoin-Induced Pseudo-Pseudolymphoma. Gams, Richard A.; Neal, Joseph A.; Conrad, Fred G. // Annals of Internal Medicine;Sep68, Vol. 69 Issue 3, p557 

    Examines the pathologic aspects of hydantoin-associated lymphadenopathy and reconsiders the possible interrelationships of the various manifestations of the syndrome. Effect of the discontinuation of diphenylhydantoin on adenopathy; Recurrence of the syndrome as a fatal malignant lymphoma;...

  • Phenytoin.  // Reactions Weekly;3/13/2010, Issue 1292, p30 

    The article describes the case of a male neonate who acquired fetal hydantoin syndrome following in utero exposure to phenytoin

  • Rostro Foundation to put smiles on faces. Torres, Giselle // Caribbean Business;5/7/1998, Vol. 26 Issue 18, p38 

    Presents information on the Rostro Foundation, a nonprofit organization, located in Puerto Rico, established by plastic surgeon Miguel A. Yanez and orthodontist Pedro Santiago, which facilitates care for craniofacial patients. Reason for the formation of the foundation; Plans of the foundation...

  • Crouzon's disease.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p548 

    An encyclopedia entry for "Crouzon's disease," which refers to an inherited congenital disease characterized by hypertelorism, is presented.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics