Kimura's Disease Associated with Ulcerative Colitis: Detection of IL-5 mRNA Expression of Peripheral Blood Mononuclear Cells and Colon Lesion

Sugaya, Makoto; Suzuki, Takehisa; Asahina, Akihiko; Nakamura, Koichiro; Ohtsuki, Mamitaro; Tamaki, Kunihiko
September 1998
Acta Dermato-Venereologica;09/01/98, Vol. 78 Issue 5, p375
Academic Journal
Case Study
Kimura's disease is considered to be a Th2 type allergic reaction based on the presence of eosinophilia and IgE hyperimmunoglobulinemia. We report a 26-year-old Japanese male with this disorder associated with ulcerative colitis. IL-5 is a selective stimulator for the production of eosinophilia and is considered to play an important role in Kimura's disease. IL-5 mRNA from peripheral blood mononuclear cells and the colon lesion were detected by the reverse-transcriptase polymerase chain reaction method, indicating that IL-5 can also be of importance in ulcerative colitis.


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