Mourão, Ana Filipa; Pinto, Teresa Laura; FaIcão, Sandra; Ribeiro, Célia; Vieira, Helena; Caetano-Lopes, Joana; Nero, Patrícia; dos Santos, Fernando Pimentel; Guimaräes, José; Branco, Jaime Cunha
April 2009
Acta Reumatológica Portuguesa;2009, Vol. 34 Issue 2, p276
Academic Journal
Case Study
Juvenile dermatomyositis (JDM) is a rare systemic disease of unknown etiology characterized by inflammation of the muscle, skin and digestive tract, with variable outcome. The diagnostic criteria include proximal symmetrical muscular weakness, characteristic skin rashes, elevation of skeletal muscle enzymes and specific electromyographic and muscle biopsy abnormalities. Pulmonary and gastro-intestinal involvements, calcinosis and generalized edema usually indicate severe disease. Recent data suggest an association between the genotype -308 AA of the Tumour Necrosis Factor (TNF) gene and disease chronicity. We present a case of a 14 year-old female with JDM and generalized oedema which is a rare manifestation of the disease and it is associated to a poor outcome.


Related Articles

  • Tumour necrosis factor antagonists.  // Reactions Weekly;5/6/2006, Issue 1100, p22 

    Presents the study "Interstitial Granulomatous Dermatitis Associated With the Use of Tumor Necrosis Factor Alpha Inhibitors," which appeared in the February 2006 issue of "Archives of Dermatology." Characteristics of the patients; Development of skin eruptions following treatment; Results of...

  • The Tumor Necrosis Factor Superfamily of Cytokines in the Inflammatory Myopathies: Potential Targets for Therapy. Paepe, Boel De; Creus, KimK.; De Bleecker, Jan L. // Clinical & Developmental Immunology;2012, p1 

    The idiopathic inflammatorymyopathies (IM) represent a heterogeneous group of autoimmune diseases, of which dermatomyositis (DM), polymyositis (PM), and sporadic inclusion bodymyositis (IBM) are the most common. The crucial role played by tumor necrosis factor alpha (TNFα) in the IM has long...

  • Is dermatomyositis in patients with rheumatoid arthritis induced by anti-TNF-α therapy? Brunasso, Alexandra; Massone, Cesare // Clinical Rheumatology;Mar2011, Vol. 30 Issue 3, p439 

    No abstract available.

  • Etanercept in psoriasis: the evidence of its therapeutic impact. Thomson, Andrew // Core Evidence;2007, Vol. 2 Issue 1, p51 

    Introduction: Psoriasis is a chronic inflammatory skin condition for which there is no cure. Treatment options are designed to control the disease symptoms and improve patients' quality of life, and physical and mental function. Established treatments can be effective but are also limited by...

  • Paradoxe Hautreaktionen unter Therapie mit TNF-α-Antagonisten. Weisenseel, P.; Reich, K. // Zeitschrift für Rheumatologie;Jun2013, Vol. 72 Issue 5, p423 

    Tumor necrosis factor α (TNF α) antagonists are an effective and established therapy option for chronic inflammatory diseases in rheumatology, gastroenterology and dermatology. However, some undesired but rare side effects of TNF α antagonists, so-called paradoxical skin reactions, have...

  • Linear ubiquitination prevents inflammation and regulates immune signalling. Gerlach, Björn; Cordier, Stefanie M.; Schmukle, Anna C.; Emmerich, Christoph H.; Rieser, Eva; Haas, Tobias L.; Webb, Andrew I.; Rickard, James A.; Anderton, Holly; Wong, Wendy W.-L.; Nachbur, Ueli; Gangoda, Lahiru; Warnken, Uwe; Purcell, Anthony W.; Silke, John; Walczak, Henning // Nature;3/31/2011, Vol. 471 Issue 7340, p591 

    Members of the tumour necrosis factor (TNF) receptor superfamily have important functions in immunity and inflammation. Recently linear ubiquitin chains assembled by a complex containing HOIL-1 and HOIP (also known as RBCK1 and RNF31, respectively) were implicated in TNF signalling, yet their...

  • Gingko biloba extract reduces VEGF and CXCL-8/IL-8 levels in keratinocytes with cumulative effect with epigallocatechin-3-gallate. Trompezinski, Sandra; Bonneville, Marlène; Pernet, Ingrid; Denis, Alain; Schmitt, Daniel; Viac, Jacqueline // Archives of Dermatological Research;Apr2010, Vol. 302 Issue 3, p183 

    In skin inflammation, vascular endothelial growth factor (VEGF) and CXCL-8/IL-8 play an important role and are produced by activated keratinocytes. Extracts from Ginkgo biloba leaves (GBE), widely used in phytotherapy, have been reported to exert antioxidant and anti-inflammatory properties in...

  • Topical Application of A Novel Immunomodulatory Peptide, RDP58, Reduces Skin Inflammation in the Phorbol Ester-Induced Dermatitis Model. de Vry, Christopher G.; Valdez, Marybeth; Lazarov, Mirella; Muhr, Evelyn; Buelow, Roland; Fong, Timothy; Iyer, Suhasini // Journal of Investigative Dermatology;Sep2005, Vol. 125 Issue 3, p473 

    RDP58 is the first lead compound in a series of immunomodulating decapeptides discovered through activity-based screening and computer-aided, rational design. RDP58 disrupts cellular responses signaled through the Toll-like and tumor necrosis factor (TNF) receptor families and occludes important...

  • Psoriasis: Targeting Therapy Towards the Inflammatory Cascade. Miteva, Mariya // American Journal of Clinical Dermatology;2010 Supplement, Vol. 11 Issue S1, p11 

    Psoriasis is a chronic inflammatory disease of the skin and joints that typically follows a relapsing/remitting disease course. Whereas psoriasis is primarily a T-cell-mediated disease, intrinsic alterations in epidermal keratinocytes also play an important role. Tumor necrosis factor alpha...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics