Pulmonary cryptococcosis in non-AIDS patients

Benquan Wu; Hui Liu; Jing Huang; Wenxian Zhang; Tiantuo Zhang
February 2009
Clinical & Investigative Medicine;Feb2009, Vol. 32 Issue 1, pE70
Academic Journal
Case Study
Purpose: To clarify the clinical features and imaging characteristics of non-AIDS patients with pulmonary cryptococcosis. Methods: We retrospectively collected 15 HIV-negative patients with pathology-proved pulmonary cryptococcosis from Sep1992 to Jan 2008. Their medical records and radiological data were reviewed and analyzed. Results: Only one patient was asymptomatic.Thirteen patients were immunocompetent and two were immunosuppressed. Three patients had associated cryptococcosis meningitis. The most common radiographic abnormalities were multiple pulmonary nodules or masses, seen in 8 and 5 cases of patients respectively. 14 patients received specific therapy for Cryptococcus neoformans. Two patients died. In the 11 patients with isolated pulmonary cryptococcosis, treatment consisted of fluconazole alone (n=7), in combination with amphotericin B (n=2), and both 5- flucytosine and amphotericin B (n=2). For the other 2 patients with cryptococcosis meningitis, one was treated with amphotericin B alone and the other with fluconazole combined with amphotericin B and 5-flucytosine. Conclusions: Non-AIDS patients might also susceptible to cryptococcosis infection. Histological examination is the principal method of diagnosis. The most common CT findings are solitary or multiple nodules with or without cavitation in the subpleural areas of the lung.


Related Articles

  • Pulmonary Cryptococcosis. Houk, Vernon N.; Moser, Kenneth M. // Annals of Internal Medicine;Oct65, Vol. 63 Issue 4, p583 

    Discusses the experience of six patients with pulmonary cryptococcosis. Localized pulmonary lesions attributable to Cryptococcus neoformans; Toxicity of amphotericin B, which is used to treat the ailment; Increased recognition of the pulmonary form of the disease; Suggestion that routine...

  • Cryptococcosis treated by rapid infusion of amphotericin B. Tarala, Richard A.; Smith, Justin D. // British Medical Journal;7/5/1980, Vol. 281 Issue 6232, p28 

    Investigates the efficacy of amphotericin B in treating pulmonary cryptococcosis. Side effects of amphotericin B; Significance of kidney secretion of amphotericin after intravenous infusion; Safety of amphotericin B infusion in treating pulmonary infection with Cryptococcus neoformans.

  • Cryptococcosis in China (1985-2010): Review of Cases from Chinese Database. Yuchong, Chen; Fubin, Che; Jianghan, Chen; Fenglian, Wei; Nan, Xu; Minghui, Yang; Yalin, Sun; Zhizhong, Zheng // Mycopathologia;Jun2012, Vol. 173 Issue 5/6, p329 

    Background: Cryptococcosis is a potential fatal disease, especially in immunocompromised patients. In China, the profile of cryptococcosis is unclear. Therefore, we summarize the epidemiology and therapy of cryptococcosis in china. Methods: All cases reports about cryptococcosis in China were...

  • Effects of Pimenta pseudocaryophyllus (Gomes) L. R. Landrum, on Melanized and Non-melanized Cryptococcus neoformans. Fátima Lisboa Fernandes, Orionalda; Costa, Carolina; Souza Lino Junior, Ruy; Vinaud, Marina; Hasimoto e Souza, Lúcia; Paula, Joelma; Rosário Rodrigues Silva, Maria // Mycopathologia;Dec2012, Vol. 174 Issue 5/6, p421 

    In the present study, the in vitro susceptibility and capsular width from both melanized and non-melanized Cryptococcus neoformans cells in the presence of Pimenta pseudocaryophyllus crude extract were determined. The results were compared with those obtained for voriconazole and amphotericin B....

  • Quercetin and rutin as potential agents antifungal against Cryptococcus spp. Oliveira, V. M.; Carraro, E.; Auler, M. E.; Khalil, N. M. // Brazilian Journal of Biology;Oct-Dec2016, Vol. 76 Issue 4, p1029 

    Amphotericin B is a fungicidal substance that is treatment of choice for most systemic fungal infections affecting as cryptococcosis the immunocompromised patients. However, severe side effects have limited the utility of this drug. The aim of this study was to evaluate the antifungal effect of...

  • Resistance of Asian Cryptococcus neoformans Serotype A Is Confined to Few Microsatellite Genotypes. Weihua Pan; Kantarawee Khayhan; Ferry Hagen; Retno Wahyuningsih; Chakrabarti, Arunaloke; Chowdhary, Anuradha; Ikeda, Reiko; Taj-Aldeen, Saad J.; Khan, Ziauddin; Imran, Darma; Sjam, Ridhawati; Sriburee, Pojana; Wanqing Liao; Chaicumpar, Kunyaluk; Ingviya, Natnicha; Mouton, Johan W.; Curfs-Breuker, Ilse; Boekhout, Teun; Meis, Jacques F.; Klaassen, Corné H. W. // PLoS ONE;Mar2012, Vol. 7 Issue 3, p1 

    Background: Cryptococcus neoformans is a pathogenic yeast that causes cryptococcosis, a life threatening disease. The prevalence of cryptococcosis in Asia has been rising after the onset of the AIDS epidemic and estimates indicate more than 120 cases per 1,000 HIV-infected individuals per year....

  • A case report of pulmonary cryptococcosis presenting as endobronchial obstruction. Qing Zhou; Bijie Hu; Changzhou Shao; Chunmei Zhou; Xing Zhang; Dong Yang; Chun Li // Journal of Thoracic Disease;Aug2013, Vol. 5 Issue 4, p170 

    Cryptococcosis presenting as endobronchial obstruction was scarce. We report a case of patient with cryptococcosis. A chest CT scan showed masses in the right upper lobe and right hilar, with evidence of narrowing of the right upper lobe bronchus. PET-CT scans showed the mass in the bronchus...

  • Role of CD4 + T cells in a protective immune response against Cryptococcus neoformans in the central nervous system. Uicker, William C.; McCracken, James P.; Buchanan, Kent L. // Medical Mycology;Feb2006, Vol. 44 Issue 1, p1 

    Cryptococcosis is a life-threatening disease caused by the encapsulated yeast, Cryptococcus neoformans . Although infection with C. neoformans is initiated in the lungs, morbidity and mortality is mostly associated with infections of the central nervous system (CNS). Individuals with...

  • Paradoxical roles of alveolar macrophages in the host response to Cryptococcus neoformans. McQuiston, Travis; Williamson, Peter // Journal of Infection & Chemotherapy (Springer Science & Business;Feb2012, Vol. 18 Issue 1, p1 

    Cryptococcus neoformans ( Cn) is a fungal pathogen that is a serious health threat to immunocompromised individuals. Upon environmental exposure, infectious fungal propagules are inhaled into the host's lungs. The anticryptococcal actions of alveolar macrophages (AM), the predominant host...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics