TITLE

Anti-M: Report of two cases and review of literature

AUTHOR(S)
Tondon, Rashmi; Kataria, Rahul; Chaudhry, Rajendra
PUB. DATE
July 2008
SOURCE
Asian Journal of Transfusion Science;Jul-Dec2008, Vol. 2 Issue 2, p81
SOURCE TYPE
Academic Journal
DOC. TYPE
Case Study
ABSTRACT
Anti-M is a fairly common naturally occurring antibody with rarely causing hemolytic transfusion reactions or hemolytic disease of the newborn. Most anti-M are not active at 37°C and can generally be ignored in transfusion practice. However, we did not find this antibody to be fairly common and detected only two cases of anti-M in the past three years. We describe these two cases; one 'immunizing' type and other 'naturally occurring' and review the literature. The immunizing type was reactive at 37°C as well as AHG phase of testing with IgG component, and showing dosage effect while the other was 'naturally occurring' reactive well below 37°C. Though rare, sometimes these antibodies can be of clinical significance when the antibody detected is reactive at 37°C and AHG phase. When the antibody is active at 37°C, M antigen negative cross match compatible red cell unit should be given.
ACCESSION #
34232855

 

Related Articles

  • Transfusion related acute lung injury (TRALI) caused by red blood cell transfusion involving residual plasma anti-HLA antibodies: A report on two cases and general considerations. Odent-Malaure, Hélène; Quainon, Fabienne; Ruyer-Dumontier, Pascale; Ducroz, Soizick; Verdier, Philippe; Voitellier, Evelyne; Raynal, Marie-Françoise; Fromont, Patricia; Muller, Jean-Yves; Rebibo, Danielle; Absi, Léna; Garraud, Olivier // Clinical & Developmental Immunology;Dec2005, Vol. 12 Issue 4, p243 

    TRALI is considered a serious hazard among immune complications of blood transfusion and its occurrence is admitted to be globally underestimated. Each type of blood product is likely to cause TRALI. We report here on two consecutive observations of TRALI caused by red blood cell concentrates,...

  • Risk of Hemolytic Transfusion Reactions Following Emergency-Release RBC Transfusion. Goodell, Pamela P.; Uhl, Lynne; Mohammed, Monique; Powers, Amy A. // American Journal of Clinical Pathology;Aug2010, Vol. 134 Issue 2, p202 

    Group O RBCs are typically issued for urgent transfusions to avoid ABO-incompatible hemolytic transfusion reactions (HTRs). Identification of other clinically significant alloantibodies requires an antibody detection test, and emergency release (ER) of RBCs before its completion carries a risk...

  • Delayed Hemolytic Transfusion Reaction Without Detectable Autoantibodies or Alloantibodies: A Possible Role of Phosphatidylserine Exposure on Donor RBCs. Mendoza, Ricardo; Moore, Marsha; Passwater, Michael; Fadeyi, Emmanuel A. // Laboratory Medicine;Nov2011, Vol. 42 Issue 11, p653 

    Delayed hemolytic transfusion reactions (DHTRs) may occur when there is an antigen mismatch between transfused RBCs and recipient RBC antibodies where sensitized RBCs are cleared by macrophages or complement activation leading to immunoglobulin G (IgG) mediated hemolysis. Some DHTR etiologies...

  • transfusion reaction.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p2358 

    An encyclopedia entry for "transfusion reaction" is presented. The term refers to an adverse reaction to a transfusion caused by the presence of foreign antigens, antibodies or cytokines. Its different types are hemolytic reactions, which occur when ABO-incompatible blood is given, allergic...

  • Indirect Tests to Detect the Non--A, Non--B Hepatitis Carrier State. Alter, Harvey J.; Holland, Paul V. // Annals of Internal Medicine;Dec84, Vol. 101 Issue 6, p859 

    Editorial. Presents information on the Transfusion-Transmitted Viruses (TTV) study of transfusion-associated hepatitis. Correlation between the presence of the antibody to the hepatitis B core antigen (anti-HBc) in donors and the occurrence of non-A and non-B hepatitis in recipients of their...

  • History and Hemolysis: Not an Easy Kidd's Game and Review of Literature. Nguyen, David M.; Wu, Ding W.; Hui Gai; Lee, Hun J. // Einstein Journal of Biology & Medicine;2010, Vol. 25/26, p12 

    The article presents a case study on the effect of transfusion in a 40-year-old woman with iron deficiency anemia and menorrhagia, involving a Kidd antibody (anti-Jkb)-induced delayed hemolytic transfusion response (DHTR). The patient faces various syndromes after transfusions of two units of...

  • Limiting the Extent of a Delayed Hemolytic Transfusion Reaction With Automated Red Blood Cell Exchange. Tormey, Christopher A.; Stack, Gary // Archives of Pathology & Laboratory Medicine;Jun2013, Vol. 137 Issue 6, p861 

    Delayed hemolytic transfusion reactions (DHTRs) are mediated by blood group antibodies that undergo anamnestic increases following antigen re-exposure. Available options for the treatment or prophylaxis of DHTRs are limited. We report the use of automated red blood cell exchange (ARE) to limit...

  • CXCL1 and its receptor, CXCR2, mediate murine sickle cell vaso-occlusion during hemolytic transfusion reactions. Jung-Eun Jang; Hod, Eldad A.; Spitalnik, Steven L.; Frenette, Paul S. // Journal of Clinical Investigation;Apr2011, Vol. 121 Issue 4, p1397 

    Hemolytic transfusion reactions (HTRs) can produce serious and potentially life-threatening complications in sickle cell disease (SCD) patients; however, the mechanisms underlying these complications remain undetermined. We established a model of alloimmune, IgG-mediated HTRs in a...

  • Washing red cells after leucodepletion does not decrease human leukocyte antigen sensitization risk in patients with chronic kidney disease. Aston, Antony; Cardigan, Rebecca; Bashir, Saber; Proffitt, Susan; New, Helen; Brown, Colin; Liesner, Ri; Hennem, Sylvia; Nulty, Helen; Shaw, Olivia; Vaughan, Robert; Kim, Jon; Rees, Lesley // Pediatric Nephrology;Oct2014, Vol. 29 Issue 10, p2005 

    Background: Standard leucodepleted blood transfusions can induce the production of human leukocyte antigen (HLA)-specific antibodies, which are associated with longer transplant waiting times and poorer graft outcomes. We hypothesized that additional washing of leucodepleted red cells might...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics