Necrotising colitis related to clozapine? A rare but life threatening side effect

Leong, Quor M.; Wong, Kutt S.; Koh, Dean C.
January 2007
World Journal of Emergency Surgery;2007, Vol. 2, p21
Academic Journal
Case Study
We report here a case of a 34-year-old gentleman who developed right-sided necrotising colitis after clozapine usage. Anticholinergic activity is believed to the cause. We believe that in patients who have been consuming medications known to have an association with necrotising colitis, constipation with concomitant increasing abdominal pain, distension and fever should be treated with a strong index of suspicion. Consideration of necrotising colitis should prompt expeditious resection of the affected colonic segment.


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