Family structure and risk factors for schizophrenia: case-sibling study

Haukka, Jari K.; Suvisaari, Jaana; Lönnqvist, Jouko
January 2004
BMC Psychiatry;2004, Vol. 4, p41
Academic Journal
Case Study
Background: Several family structure-related factors, such as birth order, family size, parental age, and age differences to siblings, have been suggested as risk factors for schizophrenia. We examined how family-structure-related variables modified the risk of schizophrenia in Finnish families with at least one child with schizophrenia born from 1950 to 1976. Methods: We used case-sibling design, a variant of the matched case-control design in the analysis. Patients hospitalized for schizophrenia between 1969 and 1996 were identified from the Finnish Hospital Discharge Register, and their families from the Population Register Center. Only families with at least two children (7914 sibships and 21059 individuals) were included in the analysis. Conditional logistic regression with sex, birth cohort, maternal schizophrenia status, and several family-related variables as explanatory variables was used in the case-sibling design. The effect of variables with the same value in each sibship was analyzed using ordinary logistic regression. Results: Having a sibling who was less than five years older (OR 1.46, 95% CI 1.29-1.66), or being the firstborn (first born vs. second born 1.62, 1.87-1.4) predicted an elevated risk, but having siblings who were more than ten years older predicted a lower risk (0.66, 0.56-0.79). Conclusions: Several family-structure-related variables were identified as risk factors for schizophrenia. The underlying causative mechanisms are likely to be variable.


Related Articles

  • BOOKS RECEIVED.  // Family Therapy: The Journal of the California Graduate School of;1996, Vol. 23 Issue 1, p76 

    The article presents a list of books including "Being a Man: A Guide to the New Masculinity," by Patrick Fanning and Matthew McKay, "Family Treatment: The Sibling Bond and Other Relationship Issues," by Edith M. Freeman, and "Family Education in Mental Illness," by Agnes B. Hatfield.

  • Flu-linked schizophrenia shows gender discrepancy.  // Psychotherapy Letter;May94, Vol. 6 Issue 5, p7 

    Presents a summary of the study `Prenatal Exposure to Influenza and the Development of Schizophrenia: Is the Effect Confined to Females,' by Noriyoshi Takei published in the `American Journal of Psychiatry' dated 1994.

  • Violence and psychosis. Taylor, Pamela J.; Gunn, John // British Medical Journal (Clinical Research Edition);6/30/1984, Vol. 288 Issue 6435, p1945 

    Examines the risk of violence among men with schizophrenia in London, England. Conduction of a survey on the records of men remanded on prison; List of conflicting hypothesis on the risk of violence in psychotic people; Suggestion to not underestimate the risk of schizophrenic violence.

  • Another Reason to Not Marry Your Cousins. Breindl, Anette // BioWorld Today;4/30/2012, Vol. 23 Issue 83, Special section p2 

    The article discusses a study which found that autozygous DNA, or DNA that is identical on both of an individual's chromosomes, may be an important risk factor for schizophrenia.

  • Risk factors.  // BMJ: British Medical Journal (International Edition);11/15/2008, Vol. 337 Issue 7679, p1177 

    The article presents a prize quiz related to risk factors for schizophrenia taken from the British Member of the Royal College of Psychiatrists examination.

  • Smoking cigarettes may increase risk, finds analysis.  // BMJ: British Medical Journal;7/18/2015, Vol. 351 Issue 8017, ph3773 

    The article discusses the association between smoking and risk of developing schizophrenia, making reference to an analysis conducted by researchers from the King's College London in England.

  • THE TAKE HOME POINTS.  // Psychiatry (1550-5952);Jul2009, Vol. 6 Issue 7, p14 

    The article lists the important points on the issue on the prodomal state of cognitive changes leading to schizophrenia.

  • Children at Risk for Schizophrenia. Kestenbaum, Clarice J // American Journal of Psychotherapy;Apr1980, Vol. 34 Issue 2, p164 

    Focuses on etiological factors attributed to the increased risks for children to develop schizophrenia. Role of gene-environment interaction; Significance of symptom clusters such as attentional deficits, poor socialization and withdrawal.

  • Schizophrenic DNA clicks into place. Holmes, Bob // New Scientist;1/25/97, Vol. 153 Issue 2066, p18 

    Reports on the link between schizophrenia and a gene that has a known function in the brain. Role of a mutation in the gene for a common brain-cell proteins; Use of genetic linkage to trace the gene responsible for defective filtering in the click test.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics