TITLE

Elevated midbrain serotonin transporter availability in mixed mania: a case report

AUTHOR(S)

Tolmunen, Tommi; Joensuu, Mikko; Saarinen, Pirjo Irmeli; Mussalo, Hanna; Ahola, Pasi; Vanninen, Ritva; Kuikka, Jyrki; Tiihonen, Jari; Lehtonen, Johannes

PUB. DATE

January 2004

SOURCE

BMC Psychiatry;2004, Vol. 4, p27

SOURCE TYPE

Academic Journal

DOC. TYPE

Case Study

ABSTRACT

Background: Results obtained from brain imaging studies indicate that serotonin transporter (SERT) and dopamine transporter (DAT) densities are altered in major depression. However, no such studies have been published on current mania or hypomania. Case presentation: In this single photon emission computed tomography (SPECT) study with [123I]nor-β-CIT we present a case with simultaneous symptoms of major depression and hypomania. She had an elevated serotonin transporter availability (SERT) in the midbrain and elevated dopamine transporter availability (DAT) in the striatum, which normalised in a one-year follow-up period during which she received eight months of psychodynamic psychotherapy. Conclusions: To our knowledge, this is the first report on SERT and DAT associated with mania. In our case the availability of both SERT in the midbrain and DAT in the striatum were elevated at baseline and declined during psychotherapy, while the SERT and DAT of the depressed controls increased during psychotherapy. Symptoms of hypomania in the case were alleviated during psychotherapy. Clinical recovery was also reflected in the Hamilton Depression Rating Scale (HDRS) scores.

ACCESSION #

29323668

 

Related Articles

• Changes in the Expression of Monoaminergic Genes under the Influence of Repeated Experience of Agonistic Interactions: From Behavior to Gene. Kudryavtseva, N. N.; Filipenko, M. L.; Bakshtanovskaya, I. V.; Avgustinovich, D. F.; Alekseenko, O. V.; Beilina, A. G. // Russian Journal of Genetics;Jun2004, Vol. 40 Issue 6, p590 

  The role of genetic and environmental factors as well as brain neurochemistry in regulating aggressive and submissive behaviors in animals are considered. We present a review of data on changes in brain monoaminergic activity (synthesis, catabolism, receptors) and on the expression of...

• Imaging of serotonin transporters and its blockade by citalopram in patients with major depression using a novel SPECT ligand [123I]-ADAM. Herold, N.; Uebelhack, K.; Franke, L.; Amthauer, H.; Luedemann, L.; Bruhn, H.; Felix, R.; Uebelhack, R.; Plotkin, M. // Journal of Neural Transmission;May2006, Vol. 113 Issue 5, p659 

  We studied the midbrain SERT availability in patients with major depression and assessed the relation of SERT occupancy by citalopram to the treatment response. 21 non-medicated patients with major depression and 13 healthy controls were examined by [123I]-ADAM SPECT. The midbrain SERT...

• On the role of the selective silencer Freud-1 in the regulation of the brain 5-HT receptor gene expression. Naumenko, V. C.; Osipova, D. V.; Tsybko, A. S // Molecular Biology;Oct2010, Vol. 44 Issue 5, p795 

  The selective 5-HT receptor silencer Freud-1 is known as one of the main factors participating in the transcriptional regulation of the serotonin brain 5-HT receptor. However, the role of Freud-1 in the mechanisms of genetically determined or exposed to experimental modification 5-HT receptor...

• Serotonin-2A receptor regulation of panic-like behavior in the rat dorsal periaqueductal gray matter: the role of GABA. Oliveira Sergio, Thatiane; Bortoli, Valquiria; Zangrossi, Helio // Psychopharmacology;Dec2011, Vol. 218 Issue 4, p725 

  Rationale: Electrical stimulation of the dorsal periaqueductal gray (dPAG) evokes escape, a defensive response associated with panic attacks. Stimulation of 5-HT1A or 5-HT2A receptors in this midbrain area equally inhibits escape performance, even though at the molecular level these receptors...

• Functional topography of midbrain and pontine serotonergic systems: implications for synaptic regulation of serotonergic circuits. Hale, Matthew; Lowry, Christopher // Psychopharmacology;Feb2011, Vol. 213 Issue 2/3, p243 

  Rationale: Dysfunction of serotonergic systems is thought to play an important role in a number of neurological and psychiatric disorders. Recent studies suggest that there is anatomical and functional diversity among serotonergic systems innervating forebrain systems involved in the control of...

• 5-hydroxytryptamine.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p1108 

  An encyclopedia entry for the medical term "5-hydroxytryptamine," also known as serotonin, is presented.

• Continuing Education Test #1141.  // RN;Aug2008, Vol. 71 Issue 8, p31 

  A quiz concerning serotonin syndrome is presented.

• Serotonin transporter binding of [123I]ADAM in bulimic women, their healthy twin sisters, and healthy women: a SPET study. Koskela, Anu K.; Keski-Rahkonen, Anna; Sihvola, Elina; Kauppinen, Tomi; Kaprio, Jaakko; Ahonen, Aapo; Rissanen, Aila // BMC Psychiatry;2007, Vol. 7, p1 

  Background: Bulimia Nervosa (BN) is believed to be caused by an interaction of genetic and environmental factors. Previous studies support the existence of a bulimia-related endophenotype as well as disturbances in serotonin (5-HT) transmission. We studied serotonin transporter (SERT) binding in...

• Serotonin is involved in the regulation of histogenetic processes in rat embryonic neocortex. E. Petrova; V. Otellin // Bulletin of Experimental Biology & Medicine;Mar2007, Vol. 143 Issue 3, p372 

  Abstract  We compared the dynamics of the development of ectopic transplants of embryonic (day 14) primordial neocortex from rats injected with serotonin inhibitor (para-chlorophenylalanine; 400 mg/kg) on day 11 of pregnancy and transplants of similar primordial neocortex incubated before...

Read the Article