A case of valproate-induced hyperammonemic encephalopathy: look beyond the liver

Alqahtani, Saleh; Federico, Paolo; Myers, Robert P.
September 2007
CMAJ: Canadian Medical Association Journal;9/11/2007, Vol. 177 Issue 6, p568
Academic Journal
Case Study
The article presents a case study of a young woman admitted to hospital with a 2-day history of decreased consciousness, nausea and vomiting. She was taking valproate for the treatment of temporal lobe epilepsy. On examination it was found that the patient had asterixis, but she had no signs of jaundice and no stigmata of chronic liver disease. The patient was found to have valproate-related hyperammonemic encephalopathy.


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