Negative anion gap and elevated osmolar gap due to lithium overdose

Sood, Manish M.; Richardson, Robert
March 2007
CMAJ: Canadian Medical Association Journal;3/27/2007, Vol. 176 Issue 7, p921
Academic Journal
Case Study
The article presents the case study of a 65-year-old man who was admitted in the hospital due to lithium overdose. It was found that this patient was normoglycemic and his urine and serum toxicology screens showed that he was positive for lithium. The patient's repeat blood work showed a negative anion gap and elevated osmolar gap. It was known that the man had a history of suicidal ideation, bipolar affective disorder, and hypertension, and he has taken long-term lithium therapy.


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