Rabkin, John M.; Corless, Christopher L.; Orloff, Susan L.; Benner, Kent G.; Flora, Ken D.; Rosen, Hugo R.; Olyaei, Ali J.
May 1998
American Journal of Gastroenterology;May1998, Vol. 93 Issue 5, p830
Academic Journal
Case Study
Fulminant hepatitis is a rare but potentially fatal adverse reaction that may occur after the use of disulfiram. A patient without a known history of liver disease was transplanted for fulminant hepatic failure secondary to disulfiram. A high index of suspicion and aggressive therapeutic approaches are essential for the prompt diagnosis and treatment of disulfiram-induced hepatic failure. The clinical presentation, histopathology, treatment, and all cases of disulfiram-induced hepatic failure reported in the English literature are reviewed. The role of orthotopic liver transplantation in a case of disulfiram-induced hepatic failure is discussed.


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