TITLE

Mid-Esophagus Columnar Metaplasia: What Is the Biopathogenic Pathway?

AUTHOR(S)
Rolim, Inês; Rodrigues, Rita Vale; Bettencourt, António; Barros, Rita; Camilo, Vânia; Pereira, António Dias; Almeida, Raquel; Chaves, Paula
PUB. DATE
May 2017
SOURCE
International Journal of Surgical Pathology;May2017, Vol. 25 Issue 3, p262
SOURCE TYPE
Academic Journal
DOC. TYPE
Case Study
ABSTRACT
We report a case of metaplastic columnar epithelium in the mid-esophagus in a patient with history of caustic ingestion. A cardiac-type gastric phenotype, with early signs of intestinalization, was confirmed by immunohistochemistry studies (MUC5AC, MUC6, SOX2, and CDX2). Nonmetaplastic mucosa had histologic evidence of gastroesophageal reflux. In this case, esophageal reepithelization seems to have been modulated by acidic gastroesophageal reflux, which might activate transcription factors leading to phenotypic reprogramming of the regenerative epithelium. Most interestingly, it is a clinical example showcasing the origin of columnar metaplasia from stem cells located within the esophageal epithelium.
ACCESSION #
122424621

 

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