TITLE

Natural killer/T-cell lymphoma-associated hemophagocytic syndrome: A case report

AUTHOR(S)
LIJUAN HAN; MINGZHI ZHANG; LING LI; LEI ZHANG; JINGJING WU; XIN LI; XINHUA WANG; YOUNG, KEN. H.; XIAORUI FU; WANG MA; ZHENCHANG SUN; XUDONG ZHANG; YU CHANG; ZHI QIAO
PUB. DATE
August 2014
SOURCE
Oncology Letters;2014, Vol. 8 Issue 2, p886
SOURCE TYPE
Academic Journal
DOC. TYPE
Case Study
ABSTRACT
Natural killer (NK)/T-cell lymphoma-associated hemophagocytic syndrome (HPS) is a rare and fatal disease with no optimal treatment. The present study reports the clinical features, diagnosis and treatment process of three patients with relapsed NK/T-cell lymphoma-associated HPS. All of the patients were classified as Ann Arbor stage IV and presented with a poor performance status. Two patients were successfully treated with a pegaspargase-containing combination regimen and one patient succumbed due to serious complications. These cases indicate that for patients with a history of lymphoma, the diagnosis of HPS should be considered when patients present with progressive high fever, pancytopenia and liver dysfunction. Early identification and effective treatments, including pegaspargase-based regimens are essential for an enhanced prognosis.
ACCESSION #
110397832

 

Related Articles

  • Aggressive mature natural killer cell neoplasms: from epidemiology to diagnosis. Lima, Margarida // Orphanet Journal of Rare Diseases;2013, Vol. 8 Issue 1, p1 

    Mature natural killer (NK) cell neoplasms are classified by the World Health Organization into NK/T cell lymphoma, nasal type (NKTCL), aggressive NK-cell leukemia (ANKCL) and chronic lymphoproliferative disorders of NK-cells, the latter being considered provisionally. NKTCL and ANKCL are rare...

  • Malignant hematopoietic cell lines: in vitro models for the study of natural killer cell leukemia–lymphoma. Drexler, H G; Matsuo, Y // Leukemia (08876924);May2000, Vol. 14 Issue 5, p777 

    Malignancies involving natural killer (NK) cells are rare disorders. The complexity of NK cell-involving disorders has only recently been appreciated. Modern classifications discern immature (precursor) from mature NK cell leukemias-lymphomas. Continuous NK leukemia-lymphoma cell lines represent...

  • Systemic EBV T-Cell Lymphoproliferative Disease of Young Adults. Kheyri, Zahedin; Mojtahedzadeh, Aydin; Zamani, Farhad; Zaremehrjerdi, Ali; Babaheidarian, Pegah // Acta Medica Iranica;2014, Vol. 52 Issue 4, p286 

    T/NK cell proliferative EBV associated disease is a rare one which is more common in eastern Asian countries. EBV is originally associated with B cells, and EBV associated T cell lymphoma is so rare. Hence we decided to describe a patient treated with misleading diagnoses such as TB and...

  • Cbl-b Deficiency Mediates Resistance to Programed Death-Ligand 1/Programed Death-1 Regulation. Fujiwara, Mai; Anstadt, Emily J.; Clark, Robert B. // Frontiers in Immunology;1/26/2017, Vol. 8, p1 

    Casitas B-lineage lymphoma-b (Cbl-b) is an E3 ubiquitin ligase that negatively regulates T cell activation. Cbl-b-/- T cells are hyper-reactive and co-stimulation independent, and Cbl-b-/- mice demonstrate robust T cell and NK cell-mediated antitumor immunity. As a result of these murine...

  • Alloreactive killer cells: hindrance and help for haematopoietic transplants. Parham, Peter; McQueen, Karina L. // Nature Reviews Immunology;Feb2003, Vol. 3 Issue 2, p108 

    Haematopoietic-cell transplantation is a treatment for leukaemia and lymphoma. To reduce the incidence of graft-versus-host disease (GVHD) caused by transplanted T cells, donors and recipients are HLA matched. For patients for whom a matched donor is not available, one option is transplantation...

  • In reply. Niewold, Timothy B.; Swaroop, Vege Santhi // Mayo Clinic Proceedings;Aug2003, Vol. 78 Issue 8, p1054 

    Replies to issues raised by Weenig and Pittelkov concerning findings of a 'Mayo Clinic Proceedings' report on the diagnosis of cutaneous T-cell lymphoma. Cross-reactivity of some polyclonal CD3 immuno-phenotyping assays with natural killer cells; Primary cutaneous T-cell lymphoma; Appearance...

  • Increased quantity of tumor-infiltrating FOXP3-positive regulatory T cells is an independent predictor for improved clinical outcome in extranodal NK/T-cell lymphoma. Kim, W. Y.; Jeon, Y. K.; Kim, T. M.; Kim, J. E.; Kim, Y. A.; Lee, S.-H.; Kim, D.-W.; Heo, D. S.; Kim, C.-W. // Annals of Oncology;Oct2009, Vol. 20 Issue 10, p1688 

    Background: Extranodal natural killer/T-cell lymphoma (NKTCL) is a clinically heterogeneous disease with a poor prognosis, requiring risk-stratified management in affected patients. Recently, tumor microenvironment including regulatory T cells (Tregs) has been implicated as a prognostic marker...

  • Ki-67 expression is predictive of prognosis in patients with stage I/II extranodal NK/T-cell lymphoma, nasal type. SJ Kim; BS Kim; CW Choi; J Choi; I Kim; Y-H Lee; JS Kim // Annals of Oncology;Aug2007, Vol. 18 Issue 8, p1382 

    Background: Localized extranodal natural killer (NK)/T-cell lymphoma, nasal type, commonly has a low or low–intermediate risk of the international prognostic index (IPI), so the IPI has shown inconsistency in predicting prognosis. Thus, we analyzed Ki-67 expression and proposed a...

  • Serum levels of the nm23-H1 protein and their clinical implication in extranodal NK/T-cell lymphoma. Niitsu, N; Okamoto, M; Honma, Y; Nakamine, H; Tamaru, J-I; Nakamura, S; Yoshino, T; Higashihara, M; Hirano, M; Okabe-Kado, J // Leukemia (08876924);May2003, Vol. 17 Issue 5, p987 

    Leukemia (2003) 17, 987-990. doi:10.1038/sj.leu.2402858

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics