Recurrence and histological evolution of dysembryoplastic neuroepithelial tumor: A case report and review of the literature

August 2013
Oncology Letters;2013, Vol. 6 Issue 4, p907
Academic Journal
Case Study
Studies of recurrent dysembryoplastic neuroepithelial tumors (DNTs) are distinctly rare. The present study reports the case of a 15-year-old female with a temporal lobe DNT, which recurred and transformed into an astrocytoma (WHO grade II) five years after an initial gross total resection (GTR). Furthermore, all the previous studies on recurrent DNT are reviewed. Although the majority of DNT cases demonstrate benign behavior, recurrent DNTs have been observed following a GTR of the tumor. Patients do not appear to benefit from post-operative adjuvant therapy, and inappropriate radiotherapy or chemotherapy may result in tumor recurrence or malignant transformation. The prognosis is favorable if a GTR of the recurrent tumor is achieved. The use of regular imaging examinations and the maintenance of a long-term follow-up is of importance following a tumor resection.


Related Articles

  • Is Survival Reduced for Patients with Anal Cancer Requiring Surgery after Failure of Radiation? Analysis from a Population Study Over Two Decades. KIRAN, RAVI P.; POKALA, NAVEEN; ROTTOLI, MATTEO; FAZIO, VICTOR W. // American Surgeon;Feb2009, Vol. 75 Issue 2, p163 

    Chemoradiotherapy is the standard treatment for anal cancer. Surgery is reserved for failure of therapy, but there are limited data examining outcomes after surgery. From a prospective population-based database on radiation and surgical therapy, we compare outcomes for patients with anal cancer...

  • Staging and treatment of osteoblastoma in the mobile spine: a review of 51 cases. Boriani, Stefano; Amendola, L.; Bandiera, S.; Simoes, C.; Alberghini, M.; Fiore, M.; Gasbarrini, A. // European Spine Journal;Oct2012, Vol. 21 Issue 10, p2003 

    Purpose: To define the role of Enneking staging system and of the consequent different treatment options on the outcome of osteoblastoma (OBL) of the spine. Methods: A retrospective review of 51 patients with OBL of the mobile spine conducted to compare the outcomes among the different types of...

  • Stereotactic radiosurgery of petroclival meningiomas: a multicenter study. Starke, Robert; Kano, Hideyuki; Ding, Dale; Nakaji, Peter; Barnett, Gene; Mathieu, David; Chiang, Veronica; Yu, James; Hess, Judith; McBride, Heyoung; Honea, Norissa; Lee, John; Rahmathulla, Gazanfar; Evanoff, Wendi; Alonso-Basanta, Michelle; Lunsford, L.; Sheehan, Jason // Journal of Neuro-Oncology;Aug2014, Vol. 119 Issue 1, p169 

    Petroclival meningiomas are difficult to treat due to their intimate location with critical structures, and complete microsurgical resection is often associated with significant morbidity. In this study, we evaluate the outcomes of petroclival meningiomas treated with Gamma Knife radiosurgery...

  • Sleeve resections with unprotected bronchial anastomoses are safe even after neoadjuvant therapy†. Storelli, Erica; Tutic, Michaela; Kestenholz, Peter; Schneiter, Didier; Opitz, Isabelle; Hillinger, Sven; Weder, Walter // European Journal of Cardio-Thoracic Surgery;Jul2012, Vol. 42 Issue 1, p77 

    OBJECTIVES Sleeve resection is the operation of choice in patients with centrally located tumours, in order to avoid a pneumonectomy. Most surgeons protect the bronchial anastomoses with tissue to prevent insufficiencies. The purpose of this study is to report on outcome of unwrapped bronchial...

  • A prospective analysis of patient outcome following treatment of T3 rectal cancer with neo-adjuvant chemoradiotherapy and transanal excision. Kennelly, Rory; Heeney, Anna; White, Anne; Fennelly, David; Sheahan, Kieran; Hyland, John; O'Connell, P.; Winter, Desmond // International Journal of Colorectal Disease;Jun2012, Vol. 27 Issue 6, p759 

    Background: Local excision is an alternative to anterior or abdomino-perineal resection in patients with early rectal cancer. In more advanced disease, neo-adjuvant therapy (CRXT) can result in significant disease regression such that local excision may be considered. The primary aim was to...

  • Reconstruction of Radiated Gluteal Defects following Sarcoma Resection with Pedicled Sensate Tensor Fascia Lata Flaps. Chao, Albert H.; Kearns, Patrick N. // Case Reports in Oncological Medicine;8/3/2015, Vol. 2015, p1 

    Sarcomas of the gluteal region often result in sizable defects following resection that are challenging to reconstruct due to their location, particularly in patients who have received radiation therapy. Reconstruction of these defects has been seldom discussed in the literature. We present two...

  • A Phase II Study of Antineoplastons A10 and AS2-1 in Children with High-Grade Glioma. Final Report (Protocol BT-06), and Review of Recent Trials. Burzynski, Stanislaw R.; Janicki, Tomasz J.; Burzynski, Gregory S.; Marszalek, Ania // Journal of Cancer Therapy;May2014, Vol. 5 Issue 6, p565 

    Standard treatment for high-grade glioma involves surgical resection followed by radiation therapy and temozolomide. Unfortunately, there are no standard treatment recommendations after recurrence and new therapies are needed for patients whose tumor recurs after first-line treatment. This...

  • The Outcome of Surgically Resected Anaplastic Astrocytoma and Glioblastoma: Results of Single Center Retrospective Study. YILMAZ, Erdal Reşit; GÜRER, Bora; KERTMEN, Hayri; DOLGUN, Habibullah; şANLI, Ahmet Metin; şEKERCI, Zeki // Journal of Neurological Sciences;2011, p347 

    Objective: Anaplastic astrocytomas and glioblastomas are the most common primary cerebral neoplasms in adults. Unfortunately, despite newly developed therapies and surgical techniques, the clinical course of anaplastic astrocytomas and glioblastomas is very rapid and almost always they have...

  • Development of methodology for conducting clinical trials in frontotemporal lobar degeneration. David S. Knopman; Joel H. Kramer; Bradley F. Boeve; Richard J. Caselli; Neill R. Graff-Radford; Mario F. Mendez; Bruce L. Miller; Nathaniel Mercaldo // Brain: A Journal of Neurology;Nov2008, Vol. 131 Issue 11, p2957 

    To design clinical trials for the frontotemporal lobar degenerations (FTLD), knowledge about measurement of disease progression is needed to estimate power and enable the choice of optimal outcome measures. The aim here was to conduct a multicentre, 1 year replica of a clinical trial in patients...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics