Recurrence and histological evolution of dysembryoplastic neuroepithelial tumor: A case report and review of the literature

August 2013
Oncology Letters;2013, Vol. 6 Issue 4, p907
Academic Journal
Case Study
Studies of recurrent dysembryoplastic neuroepithelial tumors (DNTs) are distinctly rare. The present study reports the case of a 15-year-old female with a temporal lobe DNT, which recurred and transformed into an astrocytoma (WHO grade II) five years after an initial gross total resection (GTR). Furthermore, all the previous studies on recurrent DNT are reviewed. Although the majority of DNT cases demonstrate benign behavior, recurrent DNTs have been observed following a GTR of the tumor. Patients do not appear to benefit from post-operative adjuvant therapy, and inappropriate radiotherapy or chemotherapy may result in tumor recurrence or malignant transformation. The prognosis is favorable if a GTR of the recurrent tumor is achieved. The use of regular imaging examinations and the maintenance of a long-term follow-up is of importance following a tumor resection.


Related Articles

  • Long-term outcome and survival of surgically treated supratentorial low-grade glioma in adult patients. Rezvan, Ahmadi; Christine, Dictus; Christian, Hartmann; Olga, Zürn; Lutz, Edler; Marius, Hartmann; Stephanie, Combs; Christel, Herold-Mende; Rainer, Wirtz Christian; Andreas, Unterberg // Acta Neurochirurgica;Nov2009, Vol. 151 Issue 11, p1359 

    The appropriate management of low-grade gliomas is still a matter of debate. So far, there are no randomized studies that analyze the impact of surgical resection on patient outcome. The value of the data obtained from the few retrospective reports available is often limited. In the present...

  • Temporal gliosarcoma: case report and review of literature. Murali Mohan, Kuppili Venkata; Agrawal, Amit; Shanthi, Vissa; Ramakrishna, Baddukonda Appala // Romanian Neurosurgery;Mar2015, Vol. 22 Issue 1, p112 

    First characterized by Stroebe, the gliosarcomas are highly malignant and rare primary tumor of the brain composed of neoplastic glial cells in association with spindle cell sarcomatous elements (biphasic tissue patterns). In spite of being recognized as two different pathologies studies have...

  • Oligoastrocytomas: throwing the baby out with the bathwater? Li, Cheryl; Lee, Maggie; Kaufman, Kimberley; Buckland, Michael; Wilcox, Paul; Shivalingam, Brindha; Brennan, Jeffrey; Suter, Catherine; Lum, Trina // Acta Neuropathologica;Jan2015, Vol. 129 Issue 1, p147 

    The article presents case studies of a middle aged man with large temporal lobe oligoastrocytoma (OA) and an aged man with tumors in the right frontal and temporal/insular regions. Analysis and diagnosis via morphology is mentioned. The relation of molecular heterogeneity to OA, and glioma are...

  • Malignant transformation of pleomorphic xanthoastrocytoma. Nakajima, T.; Kumabe, T.; Shamoto, H.; Watanabe, M.; Suzuki, H.; Tominaga, T. // Acta Neurochirurgica;Jan2006, Vol. 148 Issue 1, p67 

    A 31-year-old woman presented with a pleomorphic xantho-astrocytoma (PXA) manifesting as epilepsy. The tumour was partially resected. Histological examination revealed cellular pleomorphism and cytoplasmic vacuolation consistent with PXA, but no mitoses, necrosis, or endothelial proliferation....

  • Intramedullary spinal cord astrocytomas: the influence of localization and tumor extension on resectability and functional outcome. Ardeshiri, Ardeshir; Chen, Bixia; Hütter, Bernd-Otto; Oezkan, Neriman; Wanke, Isabel; Sure, Ulrich; Sandalcioglu, Ibrahim // Acta Neurochirurgica;Jul2013, Vol. 155 Issue 7, p1203 

    Background: Intramedullary spinal cord tumors (IMSCT) are rare lesions, ependymomas and astrocytomas being the most common ones. Different studies have been published showing results of different treatment strategies as extensive/ limited surgery, biopsy and adjuvant radiation therapy with...

  • Late temporal lobe necrosis after conventional radiotherapy for carcinoma of maxillary sinus. Kanakamedala, Madhava; Mahta, Ali; Liu, Jianlin; Kesari, Santosh // Medical Oncology;Dec2012, Vol. 29 Issue 4, p2456 

    Cerebral radiation necrosis is a serious late complication after conventional radiotherapy that can present with focal neurologic deficits or with more generalized signs and symptoms of increased intracranial pressure, depending on the location. The incidence and severity of radionecrosis are...

  • Effect of Primary Tumour Volumes in Early T-Stage Nasopharyngeal Carcinoma. Chang, Cheng-Chuan; Chen, Mu-Kuan; Liu, Mu-Tai; Wu, Hwa-Koon; Hwang, Kai-Lin // Journal of Otolaryngology;Mar/Apr2003, Vol. 32 Issue 2, p87 

    Objective: To investigate the relationship between primary tumour volumes and treatment outcomes in early T-stage nasopharyngeal carcinoma. Design: Retrospective study. Setting: Tertiary care centre. Method: A consecutive series of 52 newly diagnosed patients of early T-stage nasopharyngeal...

  • Chemotherapy and Delivery in the Treatment of Primary Brain Tumors. Mathieu, David; Fortin, David // Current Clinical Pharmacology;Sep2007, Vol. 2 Issue 3, p197 

    Malignant astrocytomas are aggressive neoplasms with a dismal prognosis despite optimal treatment. Maximal resective surgery is traditionally complemented by radiation therapy. Chemotherapy is typically used on patients with tumor recurrence, when their functional status is congruent with...

  • Arrested growth and spontaneous tumor regression of partially resected low-grade cerebellar astrocytomas in children. Loh, Joon-Khim; Lieu, Ann-Shung; Chai, Chee-Yin; Hwang, Shiuh-Lin; Kwan, Aij-Lie; Wang, Chih-Jen; Howng, Shen-Long // Child's Nervous System;Nov2013, Vol. 29 Issue 11, p2051 

    Purpose: The prognosis of children with low-grade cerebellar astrocytoma who have partial resection of tumor is largely unpredictable. The purpose of this study was to review the long-term outcome of such patients. Methods: The medical charts, imaging findings, operative notes, histopathological...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics