TITLE

Repeat stereotactic radiosurgery in the management of brain metastases from NSCLC: A case report and review of the literature

AUTHOR(S)
GIULIA MARVASO; AGNESE BARONE; CATERINA VACCARO; VICENTE BRUZZANITI; SILVIA GRESPI; VALERIO SCOTTI; CATALDO BIANCO
PUB. DATE
August 2013
SOURCE
Oncology Letters;2013, Vol. 6 Issue 4, p897
SOURCE TYPE
Academic Journal
DOC. TYPE
Case Study
ABSTRACT
The aims of radiotherapeutic treatment of brain metastases include maintaining neurocognitive function and improvement of survival. Based on these premises, we present a case report in which the role of repeat stereotactic radiosurgery (SRS) was investigated in a patient with a recurrent brain metastasis from non-small cell lung cancer in the same area as previously treated with radiosurgery. A 40-year-old male caucasian patient was diagnosed with brain metastasis from non-small cell lung cancer (NSCLC) and underwent SRS. The patient developed a recurrence of the disease and a second SRS on the same area was performed. After 8 months, tumor restaging demonstrated a lesion compatible with a recurrence and the patient underwent surgery. Histological diagnosis following surgery revealed only the occurrence of radionecrosis. Radiotherapy was well-tolerated and no grade 3/4 neurological toxicity occurred. To date, no consensus exists on the efficacy of retreatment with SRS. Despite the limited number of studies in this field, in the present case report, we outline the outcomes of this unconventional approach.
ACCESSION #
110397620

 

Related Articles

  • The benefit of whole brain reirradiation in patients with multiple brain metastases. Ozgen, Zerrin; Atasoy, Beste M.; Ucuncu Kefeli, Aysegul; Seker, Askin; Dane, Faysal; Abacioglu, Ufuk // Radiation Oncology;2013, Vol. 8 Issue 1, p1 

    Background: To assess the outcomes, symptom palliation and survival rates in patients who received repeat whole brain radiotherapy (WBRT). Methods: Twenty-eight patients who had progression of brain metastasis received a second course of WBRT. Univariate log-rank testing and multivariate Cox...

  • Comparison between surgical resection and stereotactic radiosurgery in patients with a single brain metastasis from non-small cell lung cancer. Bougie-Richardson, É.; Masson-Coté, L.; Mathieu, D. // Journal of Radiosurgery & SBRT;2013 Supplement 2.1, Vol. 2, p75 

    Purpose: The optimal management of patients with single brain metastasis from non-small cell lung cancer (NSCLC) remains controversial. Surgical resection and stereotactic radiosurgery (SRS) are both used in the treatment of such lesions. This study was conducted in order to compare both...

  • Novel neurocognitive-sparing radiotherapy worth its cost.  // PharmacoEconomics & Outcomes News;Sep2015, Vol. 737 Issue 1, p23 

    The article presents a study concerning the potential of neurocognitive-sparing radiation technologies for the treatment of brain metastases, such as stereotactic radiosurgery (SRS) or hippocampal-avoidance wholebrain radiotherapy (HA-WBRT), to be cost effective.

  • Whole brain radiotherapy does not increase survival in non small cell lung cancer patients treated with gamma knife radiosurgery for visible brain metastases. Hanssens, P. E. J.; Karlsson, B.; Beute, G.; Verheul, J.; S. Te Lie; Leenstra, S. // Journal of Radiosurgery & SBRT;2013 Supplement 2.1, Vol. 2, p161 

    Purpose: The role of prophylactic whole brain radiotherapy (pWBRT) following Gamma Knife Radiosurgery (GKRS) for brain metastases in patients with non small cell lung cancer (NSCLC) has been extensively discussed. The benefit of pWBRT in prolonged survival and decreased risk for brain metastases...

  • Subdivision of recursive partioning analysis (RPA) class ii patients with brain metastases treated with stereotactic radiosurgery -- bristol oncology centre results. Botten, J. C.; Robinson, T. M.; Jenner, A. V.; Douglas, L. S.; Herbert, C. C.; Hopkins, K. I.; Cameron, A. L. // Journal of Radiosurgery & SBRT;2013 Supplement 2.1, Vol. 2, p48 

    Purpose: RPA class is a validated score to predict the survival of patients with brain metastases. Unfortunately, the majority of patients fall into class two and their varying survival limits the use of the RPA as a prognostic guide. Recent studies focusing on class 2 have found that...

  • Long-Term Survival in a Patient with Multiple Brain Metastases from Small-Cell Lung Cancer Treated with Gamma Knife Radiosurgery on Four Occasions: A Case Report. Elaimy, Ameer L.; Thumma, Sudheer R.; Lamm, Andrew F.; Mackay, Alexander R.; Lamoreaux, Wayne T.; Fairbanks, Robert K.; Demakas, John J.; Cooke, Barton S.; Lee, Christopher M. // Case Reports in Neurological Medicine;2012, p1 

    Brain metastases are the most common cancerous neoplasm in the brain. The treatment of these lesions is challenging and often includes a multimodality management approach with whole-brain radiation therapy, stereotactic radiosurgery, and neurosurgery options. Although advances in biomedical...

  • Lymphopenia predicts response to stereotactic radiosurgery in lung cancer patients with brain metastases. Li, Yuping D.; Lamano, Jason B.; Kaur, Gurvinder; Lamano, Jonathan B.; Veliceasa, Dorina; Biyashev, Dauren; Kruser, Timothy; Bloch, Orin // Journal of Neuro-Oncology;Jun2019, Vol. 143 Issue 2, p337 

    Background: Stereotactic radiosurgery (SRS) can enhance immune activation and improve disease control through stimulation of anti-tumor immunity. However, patients with cancer receiving chemotherapy are often immunosuppressed, which may impact the efficacy of SRS. Here we investigate the...

  • Stereotactic Radiosurgery for Metastases in Eloquent Central Brain Locations. Hsu, Fred; Nichol, Alan; Ma, Roy; Kouhestani, Para; Toyota, Brian; McKenzie, Michael // Canadian Journal of Neurological Sciences;Sep2015, Vol. 42 Issue 5, p333 

    Background: To examine stereotactic radiosurgery (SRS) following whole brain radiotherapy for metastases in eloquent, central brain locations: brainstem, thalamus, and basal ganglia. Methods: We conducted a retrospective review of patients with metastases in eloquent, central brain locations who...

  • Surgery for brain metastases. Yaeger, Kurt Andrew; Nair, M. Nathan // Surgical Neurology International;2013, Vol. 4 Issue Supp 4, pS203 

    The use of surgery in the treatment of brain metastases is controversial. Patients who present certain clinical characteristics may experience prolonged survival with resection compared with radiation therapy. Thus, for patients with a single metastatic lesion in the setting of well-controlled...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics