TITLE

Arnold Chiari Malformation with Spina Bifida: A Lost Opportunity of Folic Acid Supplementation

AUTHOR(S)
GANESH, DEEPA; SAGAYARAJ, BENJAMIN M.; BARUA, RAVI KUMAR; SHARMA, NIDHI; RANGA, UPASANA
PUB. DATE
December 2014
SOURCE
Journal of Clinical & Diagnostic Research;Dec2014, Vol. 8 Issue 12, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Case Study
ABSTRACT
In Arnold Chiari (kee-AHR-ee) II malformation elongated cerebellar tonsils are displaced inferiorly through the Foramen Magnum into the upper cervical spinal canal. It is a complex anomaly with skull, dura, brain, spine and cord manifestations. Meningomyelocele is seen in all cases. We present a case of type II Arnold Chiari Malformation diagnosed in utero in a pregnant lady .There was no periconceptional folic acid supplementation. As the role of the Methylene Tetra Hydro Folate Reductase gene polymorphism in neural tube defects is becoming evident, a simple opportunity as folic acid supplementation should not be missed. Folate supplementation as fortification of cereal grains will also prevent other conditions like congenital heart defects, urinary tract anomalies, orofacial defects, limb defects and pyloric stenosis.
ACCESSION #
101632992

 

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