TITLE

Intra-Abscess Administration of Antibiotics Through Ultrasound—Guided Percutaneous Catheter for the Treatment of Pyogenic Liver Abscess

AUTHOR(S)
ALVAREZ-URIA, GERARDO; PAKAM, RAGHAVAKALYAN; MIDDE, MANORANJAN; NAIK, PRAVEEN KUMAR
PUB. DATE
August 2013
SOURCE
Journal of Clinical & Diagnostic Research;Aug2013, Vol. 7 Issue 8, p1698
SOURCE TYPE
Academic Journal
DOC. TYPE
Case Study
ABSTRACT
Pyogenic liver abscess is a potentially life-threatening disease. The treatment of a pyogenic liver abscess usually involves ultrasound guided percutaneous drainage because of the poor penetration of the systemic administration of antibiotics inside the abscess. However, a sizable proportion of patients will necessitate surgical interventions, which involves high peri- and post-operative risks. Theoretically, the local instillation of antibiotics inside the pyogenic liver abscess fluid could achieve a high concentration of the antibiotic for a long period of time. This could be especially beneficial for time-dependent bactericidal antibiotics such as beta-lactams, because their bactericidal effectiveness depends on the amount of time that bacteria are exposed to the antibiotic. We are reporting two patients with complicated pyogenic liver abscesses, who were successfully treated with systemic antibiotics and local instillation of meropenem inside the cavities of the abscesses. These cases suggest that the local instillation of the beta-lactam antibiotics could be an effective and a safe strategy for the treatment of pyogenic liver abscesses that cannot be completely drained through an ultrasound guided percutaneous catheter.
ACCESSION #
101604819

 

Related Articles

  • Meticillin-resistant Staphylococcus aureus liver abscess. Jackson, Hannah; Bhalme, Mahesh; Quest, Laura // British Journal of Hospital Medicine (17508460);Jan2012, Vol. 73 Issue 1, p48 

    The article presents a case study of a 78- year old man unwell with upper abdominal pain and vomiting who had a history of hypertension and chronic back pain. Investigations revealed a liver abscess that was drained radiologically and meticillin-resistant Staphylococcus aureus was isolated...

  • Defining the Role of Novel β-Lactam Agents That Target Carbapenem-Resistant Gram-Negative Organisms. Tamma, Pranita D; Hsu, Alice J // Journal of the Pediatric Infectious Diseases Society;Sep2019, Vol. 8 Issue 3, p251 

    With the current carbapenem-resistant organism crisis, conventional approaches to optimizing pharmacokinetic-pharmacodynamic parameters are frequently inadequate, and traditional salvage agents (eg, colistin, tigecycline, etc) confer high toxicity and/or have low efficacy. However, several...

  • Risk factors, management, and prognosis for liver abscess after radical resection of hilar cholangiocarcinoma. Changxi Zhang; Tao Li; Zhiqiang Chen; Qiangpu Chen; Xuting Zhi // International Journal of Clinical & Experimental Medicine;2015, Vol. 8 Issue 11, p21279 

    Objectives: Pyogenic liver abscess (PLA) is a rare but potentially lethal infectious complication after radical surgical resection of hilar cholangiocarcinoma (HC), this study is aimed to identify the risk factors, management and prognosis of PLA after curative surgical resection of HC. Methods:...

  • Bacterial Temporal Dynamics Enable Optimal Design of Antibiotic Treatment. Meredith, Hannah R.; Lopatkin, Allison J.; Anderson, Deverick J.; You, Lingchong // PLoS Computational Biology;Apr2015, Vol. 11 Issue 4, p1 

    There is a critical need to better use existing antibiotics due to the urgent threat of antibiotic resistant bacteria coupled with the reduced effort in developing new antibiotics. β-lactam antibiotics represent one of the most commonly used classes of antibiotics to treat a broad spectrum of...

  • AMEBIC LIVER ABSCESS; INCODENCE AND OUTCOME. Khan, Rana Asrar Ahmad; Hameed, Fakhar; Bashir, M. Badar; Rana, Mohamad Mohsin; Mazhar, Hamed Raza // Professional Medical Journal;Oct2010, Vol. 17 Issue 4, p527 

    Amoebic liver abscess is a common infection in third world countries like ours due to poor sanitary arrangements. It presents with severe pain and high grade fever and if not diagnosed and treated promptly, may lead to complications and mortality. Objectives: To estimate the incidence, need for...

  • Inferior vena caval and right atrial thrombosis: Complicating pyogenic liver abscess. Bagri, Narendra; Yadav, Dinesh; Hemal, Alok // Indian Pediatrics;Jul2013, Vol. 50 Issue 7, p701 

    Vascular complication of liver abscess are rare but life-threatening. We herein report a 2 year 9 month boy with pyogenic hepatic abscess complicated by inferior vena cava thrombus extending to right atrium. Early clinical suspicion aided by ultrasonography and echocardiography confirmed the...

  • Presentation and Management of Pyogenic Liver Abscess in a 23-Week Pregnant Woman. Yüksel, Beril; Seven, Ali; Kucur, Suna; Gözükara, Ilay; Keskin, Nadi // Case Reports in Obstetrics & Gynecology;2013, p1 

    Pyogenic liver abscess during pregnancy is an extremely rare condition. We report a case of 33-year-old, 23-week pregnant woman with pyogenic liver abscess. She was still in the hospital for medical observation of fever, when a sudden episode of tachycardia with a pulse of 210 beats per minute...

  • Continuous versus Intermittent β-Lactam Infusion in Severe Sepsis. A Meta-analysis of Individual Patient Data from Randomized Trials. Roberts, Jason A.; Abdul-Aziz, Mohd-Hafiz; Davis, Joshua S.; Dulhunty, Joel M.; Cotta, Menino O.; Myburgh, John; Bellomo, Rinaldo; Lipman, Jeffrey // American Journal of Respiratory & Critical Care Medicine;9/15/2016, Vol. 194 Issue 6, p681 

    Rationale: Optimization of β-lactam antibiotic dosing for critically ill patients is an intervention that may improve outcomes in severe sepsis.Objectives: In this individual patient data meta-analysis of critically ill patients with severe sepsis, we aimed to...

  • Treatment of Uncomplicated Acute Appendicitis. Minneci, Peter C.; Deans, Katherine J. // JAMA: Journal of the American Medical Association;10/6/2015, Vol. 314 Issue 13, p1401 

    A letter to the editor is presented which discusses the Appendicitis Acuta (APPAC) trial regarding the comparison between antibiotics and appendectomy in treating patients with uncomplicated acute appendicitis.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics