Role of epidermal growth factor receptor activation in epithelial cell repair and mucin production in airway epithelium

Burgel, P.-R.; Nadel, J. A.
November 2004
Thorax;Nov2004, Vol. 59 Issue 11, p992
Academic Journal
Book Chapter
The article focuses on mechanisms involved in mucus hypersecretion and in epithelial damage and repair. Mucous hypersecretion contributes to morbidity and mortality in various airway inflammatory diseases such as asthma, COPD, cystic fibrosis and nasal polyposis, but no treatment to prevent hypersecretion currently exists. Airway mucus hypersecretion can occur with limited clinical symptoms, especially in peripheral airways where cough receptors are absent and where extensive mucous plugging may be undetected by pulmonary function tests and reproducible biological measurement of mucus production in airway secretions in human diseases is difficult.


Related Articles

  • A MARCKS-related peptide blocks mucus hypersecretion in a mouse model of asthma. Singer, Monique; Martin, Linda D.; Vargaftig, B. Boris; Park, Joungjoa; Gruber, Achim D.; Li, Yuehua; Adler, Kenneth B. // Nature Medicine;Feb2004, Vol. 10 Issue 2, p193 

    Mucus hypersecretion is a crucial feature of pulmonary diseases such as asthma, chronic bronchitis and cystic fibrosis. Despite much research, there is still no effective therapy for this condition. Recently, we showed that the myristoylated, alanine-rich C-kinase substrate (MARCKS) protein is...

  • STAT6 Links IL-4/IL-13 Stimulation With Pendrin Expression in Asthma and Chronic Obstructive Pulmonary Disease. Nofziger, C.; Vezzoli, V.; Dossena, S.; Schönherr, T.; Studnicka, J.; Nofziger, J.; Vanoni, S.; Stephan, S.; Silva, M. E.; Meyer, G.; Paulmichl, M. // Clinical Pharmacology & Therapeutics;Sep2011, Vol. 90 Issue 3, p399 

    Signaling through the interleukin-4/interleukin-13 (IL-4/IL-13) receptor complex is a crucial mechanism in the development of bronchial asthma and chronic obstructive pulmonary disease (COPD). In bronchial epithelial cells, this signaling pathway leads to changes in the expression levels of...

  • The CLCA Gene Family: Putative Therapeutic Target for Respiratory Diseases. Winpenny, John P.; Marsey, Laura L.; Sexton, Darren W. // Inflammation & Allergy - Drug Targets;Jun2009, Vol. 8 Issue 2, p146 

    The CLCA proteins were first shown to exist in bovine trachea and named as chloride channels calcium activated (CLCA) due to the calcium-dependent chloride conductance that appeared to be activated on expression of these proteins in trachea and other secretory epithelial cells. Since their...

  • Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Kuperman, Douglas A.; Huang, Xiaozhu; Koth, Laura L.; Chang, Grace H.; Dolganov, Gregory M.; Zhu, Zhou; Elias, Jack A.; Sheppard, Dean; Erle, David J. // Nature Medicine;Aug2002, Vol. 8 Issue 8, p885 

    Asthma is an increasingly common disease that remains poorly understood and difficult to manage. This disease is characterized by airway hyperreactivity (AHR, defined by exaggerated airflow obstruction in response to bronchoconstrictors), mucus overproduction and chronic eosinophilic...

  • HIV gp120 Induces Mucus Formation in Human Bronchial Epithelial Cells through CXCR4/α7-Nicotinic Acetylcholine Receptors. Gundavarapu, Sravanthi; Mishra, Neerad C.; Singh, Shashi P.; Langley, Raymond J.; Saeed, Ali Imran; Feghali-Bostwick, Carol A.; McIntosh, J. Michael; Hutt, Julie; Hegde, Ramakrishna; Buch, Shilpa; Sopori, Mohan L. // PLoS ONE;Oct2013, Vol. 8 Issue 10, p1 

    Lung diseases such as chronic obstructive pulmonary disease (COPD), asthma, and lung infections are major causes of morbidity and mortality among HIV-infected patients even in the era of antiretroviral therapy (ART). Many of these diseases are strongly associated with smoking and smoking is more...

  • Role of microRNAs in lung development and pulmonary diseases. Sessa, Roberto; Hata, Akiko // Pulmonary Circulation;Apr-Jun2013, Vol. 3 Issue 2, p315 

    MicroRNAs (miRNAs) are a class of small noncoding RNA which exert post-transcriptional gene regulation activity by targeting messenger RNAs. miRNAs have been found to be involved in various fundamental biological processes and deregulation of miRNAs is known to result in pathological conditions....

  • Sex differences in mouse models of asthma. Chang, Herng-Yu Sucie; Mitzner, Wayne // Canadian Journal of Physiology & Pharmacology;Dec2007, Vol. 85 Issue 12, p1226 

    Differences in disease susceptibility and prognosis between men and women are known to occur in the incidence and development of neurodegenerative, cardiovascular, and immunological disorders. In the lung there are also sex-based differences in the incidence, prevalence, and pathogenesis of lung...

  • Rhinovirus exposure impairs immune responses to bacterial products in human alveolar macrophages. Oliver, B. G. G.; Lim, S.; Wark, P.; Laza-Stanca, V.; King, N.; Black, J. L.; Burgess, J. K.; Roth, M.; Johnston, S. L. // Thorax;Jun2008, Vol. 63 Issue 6, p519 

    Background: Rhinovirus infection is responsible for considerable morbidity and mortality as the major cause of exacerbations of asthma, and is also known to induce exacerbations of cystic fibrosis and chronic obstructive pulmonary disease. Exacerbations of these diseases are also frequently...

  • Following Nero: fiddle while Rome burns, or is there a better way? Bush, Andrew; Pavord, Ian // Thorax;May2011, Vol. 66 Issue 5, p367 

    The author comments on the use of the term exacerbation in describing severity of asthma or chronic obstructive pulmonary disease in relation to a proposal to discard the term in favor of the phrase lung attack. The author criticizes the generally accepted view of exacerbation and discusses how...


Read the Article


Sign out of this library

Other Topics