Association between the proportion of dominant follicles and oocyte developmental competence

Li, Yi; Li, Rui-Qi; Ou, Song-Bang; Ren, Ling; Zhang, Ning-Feng; Wei, Li-Na; Zhang, Qing-Xue; Yang, Dong-Zi
December 2014
Journal of Assisted Reproduction & Genetics;Dec2014, Vol. 31 Issue 12, p1599
Academic Journal
Purpose: To explore the optimal timing for hCG triggering by investigating the impact of different proportion of dominant follicles on the oocyte developmental competence. Methods: One hundred ninety-eight infertile women were divided into three groups according to the proportion of dominant follicles on hCG day: (1) low: <15 % ( n = 66); (2) middle: 15-27 % ( n = 66); (3) high: >27 % ( n = 66). The grouping criteria were the bottom and top tertiles of the proportion of dominant follicles. Results: The gonadotropin dosage, duration and maximum follicle diameter in the low proportion group were lower than those in the middle and high proportion groups. Oocyte maturation and the abnormal fertilization rate in the low proportion group were lower than those in the middle and high proportion groups. The normal fertilization rate did not differ among the three groups. The cleavage rate and number of transferable embryos in the low proportion group were significantly higher than those in the high proportion group. The high-quality embryo rate, implantation rate, and pregnancy rate in the low proportion group were significantly higher than those in the middle and high proportion groups. Conclusions: A high proportion of dominant follicles are closely associated with impaired oocyte developmental competence and low pregnancy rate. These findings suggest that follicular overgrowth induced by delayed hCG triggering may undermine oocyte developmental competence and the proportion of dominant follicles may be a potential parameters for hCG triggering.


Related Articles

  • Combining uFSH and rFSH Improves Oocyte Maturity and Embryo Cleavage.  // Fertility Weekly;12/24/2007, p6 

    The article discusses the effects of the combination of urinary FSH (uFSH) and recombinant FSH (rFSH) on ovarian stimulation in improved maturity and embryo cleavage. Accordingly, controlled ovarian hyperstimulation (COH) is a fundamental part of in vitro fertilization (IVF) and embryo transfer...

  • Embryo selection: the role of time-lapse monitoring. Kovacs, Peter // Reproductive Biology & Endocrinology;2014, Vol. 12 Issue 1, p30 

    In vitro fertilization has been available for over 3 decades. Its use is becoming more widespread worldwide, and in the developed world, up to 5% of children have been born following IVF. It is estimated that over 5 million children have been conceived in vitro. In addition to giving hope to...

  • Routine Use is Inappropriate but is Beneficial for Some Patients.  // Fertility Weekly;9/5/2011, p3 

    The article focuses on the review regarding the routine use of assisted hatching (AH) as method to improve the implantation rates. It states that AH methods involve disruption of the zona pellucida including drilling, zona thinning, or complete removal of the zona pellucida. It notes that the...

  • Cumulus cell-oocyte complexes retrieved from antral follicles in IVM cycles: relationship between COCs morphology, gonadotropin priming and clinical outcome. Dal Canto, Mariabeatrice; Brambillasca, Fausta; Mignini Renzini, Mario; Coticchio, Giovanni; Merola, Maria; Lain, Monia; De Ponti, Elena; Fadini, Rubens // Journal of Assisted Reproduction & Genetics;Jun2012, Vol. 29 Issue 6, p513 

    Purpose: To assess retrospectively the developmental potential of different types of cumulus cell-oocyte complexes (COCs) derived from IVM cycles. Methods: IVM cycles were performed in natural cycles or after HCG, FSH, or FSH/HCG priming. COCs recovered were morphologically characterized in...

  • Conventional stimulation protocol failed to produce mature oocytes : rescue ivm resulted in six pregnancies after invitro fertilization and embryo transfer. Gunasheela, Sulochana; Gunasheela, Devika; Gupta, Santosh; Peter, Joshua // Journal of Experimental Sciences;2011, Vol. 2 Issue 11, p14 

    When conventional stimulation protocol in IVF cycle fails to produce mature oocytes, many a times, the cycle is cancelled and the patient is disappointed. Now that in-vitro maturation of oocyte is possible in view of commercial availability of media, perhaps it may be mandatory to retrieve...

  • Effect of adding human chorionic gonadotropin to frozen thawed embryo transfer cycles with history of thin endometrium. Davar R.; Farid Mojtahedi M.; Miraj S. // Iranian Journal of Reproductive Medicine;Apr2015 Supplement, p63 

    Introduction: Embryo implantation process is a complex phenomenon and depends on fetal and maternal factors interaction. Endometrial thickness is needed for successful implantation. Increasing endometrial thickness, raise the chance of clinical pregnancy. The triple line pattern, with thickening...

  • Effects of in vivo exposure to eggs with sperm-immobilizing antibodies in follicular fluid on subsequent fertilization and embryo development in vitro. Shibahara, Hiroaki; Hirano, Yuki; Shiraishi, Yasuko; Shimada, Kazuhiko; Kikuchi, Kumiko; Suzuki, Tatsuya; Takamizawa, Satoru; Suzuki, Mitsuaki // Reproductive Medicine & Biology;Jun2006, Vol. 5 Issue 2, p137 

    Aims: It has been shown that supplementation of patients’ sera that contains sperm-immobilizing antibodies results in failure of fertilization and embryo development in vitro. The present study was carried out to investigate if exposing retrieved eggs to a high number of...

  • Recovery and Preservation of Goat Follicular Oocytes. Khillare, K. P. // Veterinary World;Mar2008, Vol. 1 Issue 3, p73 

    The article reports on a study that examines the supply of follicular oocytes of goats that can be recovered and preserved in vitro maturation and in vitro fertilization (IVF) of embryo transfer. With the use of technological methods, one can obtain embryos in abundant quantity of transgenic...

  • Embriyo transfer öncesi endometrial ko-kültür uygulamaları. Bahar, Leyla; Eras, Nazan // Genel Tip Dergisi;2012, Vol. 22 Issue 1, p31 

    Objective: It can be considered that the factors which affect the success of embryo implantation, embryo quality, embryo transfer (ET) technique and endometrial receptivity are the main ones. New methods were applied with the practices of invitro fertilization for the women who failed for...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics