Metabolic disease: Mitochondrial uncoupler reverses diabetes

Crunkhorn, Sarah
December 2014
Nature Reviews Drug Discovery;Dec2014, Vol. 13 Issue 12, p885
Academic Journal
The article discusses the development of insulin resistance and hyperglycaemia which use to treat type 2 diabetes (T2D) by reducing the accumulation of lipids in metabolically sensitive organs. It examines the impact of mitochondrial uncoupler to energy inefficiency and increased energy expenditure for the reduction of intracellular lipid content. It stresses the utilization of niclosamide ethanolamine salt (NEN) for a high-fat diet (HFD) in mice.


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