崔晓海; 李晓军; 王健生; 赵 阳; 张 靖; 李 刚; 曹培龙
November 2014
Journal of Xi'an Jiaotong University (Medical Sciences);Nov2014, Vol. 35 Issue 6, p852
Academic Journal
Objective To investigate the protective role of atrial natriuretics peptide(ANP) in acute lung injury after tracheal replacement in rabbits. Methods Twenty-four adult New Zealand rabbits were randomly divided into ANP group and control group to receive PTFE tracheal replacement. On day 3 after surgery the rabbits were killed; wet-to-dry weight ratio of the lungs and atrial PaO2 were examined under light microscope for the pathological changes of the lungs to evaluate acute lung injury. Results Compared with control group, PaO2 was significantly increased with significantly decreased W/D weight ratio in ANP group (P<0.05). Pulmonary edema was more severe in control group than in ANP group. Conclusion ANP can effectively alleviate acute lung injury in rabbits after PTFE tracheal replacement.


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