TITLE

补肾活血方联合地屈孕酮对复发性流产患者临床疗效及Th1/Th2型细胞因子的

AUTHOR(S)
党慧敏; 刘艳巧; 刘润侠; 陈 薇; 安 鹏; 刘军花
PUB. DATE
November 2014
SOURCE
Journal of Xi'an Jiaotong University (Medical Sciences);Nov2014, Vol. 35 Issue 6, p833
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective To investigate the effects of Bushen Huoxue Fang (BSHXF) combined with dydrogesterone on clinical efficacy and immunoregulation in patients with recurrent spontaneous abortion (RSA). Methods We randomly assigned 62 pregnant patients with RSA, whose traditional Chinese medicine (TCM) syndrome differentiation was of the type of kidney deficiency and blood stasis into three groups. In the Chinese medicine group 21 patients were treated with BSHXF, in the Western medicine group 20 patients were treated with dydrogesterone, and in the integrative medicine group 21 patients were given a combination of both. In addition, 20 women with normal pregnancy were randomly selected as the control group, without given any medication. We observed the changes of TCM syndrome scores and TCM syndome efficacy clinical efficacy, serum levels of IL-2 and IL-10, and the ratio of IL-2/IL-10 in each group before and after treatment. Results After treatment the TCM syndrome scores in the integrative medicine group was better than that in the Western medicine group (P<0.05). After treatment, the serum level of IL-10 in each treatment group was significantly higher than before, while the serum IL-2 level and the ratio of IL-2/IL-10 were significantly lower than before (P<0.01). After treatment, compared with the Chinese medicine group and Western medicine group, the serum IL-10 levels were increased in the integrative medicine group, and the serum IL-2 levels and the ratio of IL-2/IL-10 were decreased in the integrative medicine group (P<0.05). In contrast, the Chinese medicine group and Western medicine group did not differ significantly (P>0.05). Conclusion BSHXF combined with dydrogesterone has a definite clinical efficacy in treating RSA patients whose TCM syndrome differentiation is of the type of kidney deficiency and blood stasis. It can regulate the balance of immunity on the whole to maintain the patients' pregnancy.
ACCESSION #
99643695

 

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