骨转录因子Runx2和骨桥蛋白OPN在人乳腺癌 组织中的表达及其与乳腺癌微钙化

梁晓燕; 马少君; 王 原; 康晓丽; 王 涛; 黄范利; 王 宏
November 2014
Journal of Xi'an Jiaotong University (Medical Sciences);Nov2014, Vol. 35 Issue 6, p828
Academic Journal
Objective To explore the expressions of Runx2 and osteopontin (OPN) in human breast cancer tissue and their association with the formation of microcalcification. Methods The expressions of Runx2 and OPN were detected in breast cancer tissue of 62 cases by immunohistochemical method. Then the 62 cases were divided into three groups: non-microcalcification, mild-microcalcification and high-microcalcification groups according to the amount of microcalcification shown on mammography in breast cancer. The association of Runx2 and OPN expressions with microcalcification was further studied. Results The positive expression rate of Runx2 and OPN in human breast cancer tissue was 72.6% and 79.0%, respectively. The positive expression of Runx2 and OPN proteins was significantly correlated with the amount of microcalcification, but not with the morphology of microcalcification in breast cancer tissue. The positive rate of Runx2 and OPN was gradually elevated with the increase in the amount of microcalcification (x2=15.686, P<0.05; x2=16.161, P<0.05), respectively. Conclusion Runx2 and OPN proteins are highly expressed in human breast cancer tissue and they may participate in the process of microcalcification formation in breast cancer.


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