TITLE

无创正压通气对AECOPD患者呼吸肌疲劳的治疗作用

AUTHOR(S)
尚 东; 党晓敏; 杨 岚; 韩建峰; 孙忠民; 冯思芳; 阳 甜; 马爱群
PUB. DATE
November 2014
SOURCE
Journal of Xi'an Jiaotong University (Medical Sciences);Nov2014, Vol. 35 Issue 6, p824
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective A randomized parallel control study was conducted to evaluate the effect of non-invasive positive pressure ventilation (NPPV) on early treatment of patients with mild acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods We selected 40 patients with mild AECOPD according to the inclusion and exclusion criteria and randomly divided them into NPPV group and control group. The changes of blood gas index and respiratory muscle fatigue index as well as hospitalization cost were observed before and after treatment. Results There was no significant difference in PaCO2 or pH value between NPPV group and control group. PaO2 [(79.81±50.3)mmHg] significantly increased at 2h after treatment in NPPV group compared with that in control group [(64.29±33.2)mmHg] (P<0.05). The phrenic nerve action potential significantly increased in NPPV group [(200.0±54.0)μV] compared with that before treatment (127.0±36.0)μV and that in control group [(150.0±52.0)μV] (P<0.05). In NPPV group, six-minute walk distance [(400.2±70.5)m] increased compared with that before treatment [(340.19±60.8)m] and it was significantly different from that in control group [(338.4±70.9)m] (P<0.05). The length of hospital stay shortened but hospitalization cost increased in NPPV group compared with those in control group. Conclusion NPPV can improve PaO2, relieve respiratory muscle fatigue, and improve activity tolerance in patients with mild AECOPD after early intervention treatment, but does not improve PaCO2 or pH.
ACCESSION #
99643693

 

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