Serum Omentin-1 Level in Diabetic Patients on Haemodialysis: a pilot study

Kocijancic, M.; Vujicic, B.; Racki, S.; Zaputovic, L.; Dvornik, S.
October 2014
Biochemia Medica;2014 Supplement, Vol. 24, pS65
Academic Journal
Background: The most common cause in the incidence of end stage renal disease (ESRD) is diabetes mellitus. The main cause of mortality in diabetes positive dialysis patients is cardiovascular disease (CVD). It's important to identify and prevent cardiovascular risk factors in dialysis patients. The serum omentin-1 level was found to be associated with cardio- metabolic disorders such as insulin resistance, diabetes, dyslipidemia and CVD. Omentin- 1 may play an important role in the pathogenesis of atherosclerosis and it may be predictive parameter of co morbidities associated with obesity and glucose metabolism. The aim of this study was to examine possible clinical significance of serum omentin-1 level in haemodialysis (HD) patients. Methods: A total of 60 prevalent HD patients at Clinical Hospital Center Rijeka were included in the cross-sectional study. Patients were divided into two groups according to presence of diabetes. Venous blood sample was withdrawn after an overnight fasting before midweek HD session. Serum omentin-1 level was assessed by enzyme-linked immunosorbent assay. Results: Diabetes negative group was comprised 26 subjects: 16 males and 10 females of average ages 67 (range 33-88) and diabetes positive group was comprised 34 subjects: 25 males and 9 females of average ages 70 (range 31-87). Omentin-1 levels of diabetic HD patients were found to be lower than of non-diabetic HD patients (8,4±3,8 μg/l vs. 12,7±2,9 μg/l, respectively; P<0,001). Conclusions: Serum omentin-1 levels were significantly lower in diabetic HD patients. We believe that decreased omentin-1 levels could play an important role in progression of atherosclerosis through its action on the vascular endothelial inflammatory state in this patients group. Further investigation in prospective clinical study with greater number of patients is needed.


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