TITLE

Introduction of Interleukin-18 genotype as a risk factor for allergic rhinitis in Chaharmahal va Bakhtiari province

AUTHOR(S)
Ramazi, S. H.; Motovalibashi, M.; Chaloshtari, M. Hashemzade; Khazraei, H. R.
PUB. DATE
December 2014
SOURCE
Journal of Shahrekord University of Medical Sciences;Dec2014/Jan2015, Vol. 16 Issue 5, p76
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background and aims: The Interleukin-18 (IL-18) is a member of the IL-1 family. It was originally described as IFN-γ -inducing factor (IGIF), and is known to influence the balance of Th1/Th2 immune response and could induce the allergic rhinitis (AR) expression. The aim of this study was to investigate whether the IL-18 promoter polymorphism (-133 G/C) were associated with AR in Chaharmahal va Bakhtiari province. Methods: In this descriptive analytical study, genomic DNA was obtained from the blood samples of 293 AR patients and 218 healthy control volunteers extracted by standard phenol chloroform method. The IL-18 polymorphism was analyzed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis. Results: The frequency of the GC genotype of the IL-18 gene polymorphism (-133) was greater in allergic rhinitis patients than in control (P<0.05). The rate of increaser distribution was calculated 3.69 by comparing the frequency of the G allele genotype to the genotype a carrier no allele G (CC) in both groups. Conclusion: This study suggests that IL-18 promoter polymorphism (-133 G/C) may be participated as a risk factor in the pathogenesis of AR.
ACCESSION #
99642035

 

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