Molecular functions and significance of the MTA family in hormone-independent cancer

Ning, Zhifeng; Gan, Jinfeng; Chen, Chaoying; Zhang, Dianzheng; Zhang, Hao
December 2014
Cancer & Metastasis Reviews;Dec2014, Vol. 33 Issue 4, p901
Academic Journal
The members of the metastasis-associated protein (MTA) family play pivotal roles in both physiological and pathophysiological processes, especially in cancer development and metastasis, and their role as master regulators has come to light. Due to the fact that they were first identified as crucial factors in estrogen receptor-mediated breast cancer metastasis, most of the early studies focused on their hormone-dependent functions. However, the accumulating evidence shows that the members of MTA family are deregulated in most, if not all, the cancers studied so far. Therefore, the levels as well as the activities of the MTA family members are widely accepted as potential biomarkers for diagnosis, prognosis, and predictors of overall survival. They function differently in different cancers with specific mechanisms. p53 and HIF-1α appear to be the respectively common upstream and downstream regulator of the MTA family in both development and metastasis of a wide spectrum of cancers. Here, we review the expression and clinical significance of the MTA family, focusing on hormone-independent cancers. To illustrate the molecular mechanisms, we analyze the MTA family-related signaling pathways in different cancers. Finally, targeting the MTA family directly or the pathways involved in the MTA family indirectly could be invaluable strategies in the development of cancer therapeutics.


Related Articles

  • Optimal tumor sampling for immunostaining of biomarkers in breast carcinoma. Tolles, Juliana; Yalai Bai; Baquero, Maria; Harris, Lyndsay N.; Rimm, David L.; Molinaro, Annette M. // Breast Cancer Research;2011, Vol. 13 Issue 3, p1 

    Introduction: Biomarkers, such as Estrogen Receptor, are used to determine therapy and prognosis in breast carcinoma. Immunostaining assays of biomarker expression have a high rate of inaccuracy; for example, estimates are as high as 20% for Estrogen Receptor. Biomarkers have been shown to be...

  • MiR-190b, the highest up-regulated miRNA in ERα-positive compared to ERα-negative breast tumors, a new biomarker in breast cancers? Cizeron-Clairac, Geraldine; Lallemand, François; Vacher, Sophie; Lidereau, Rosette; Bieche, Ivan; Callens, Celine // BMC Cancer;Jul2015, Vol. 15 Issue 1, p1 

    Background: MicroRNAs (miRNAs) show differential expression across breast cancer subtypes and have both oncogenic and tumor-suppressive roles. Numerous microarray studies reported different expression patterns of miRNAs in breast cancers and found clinical interest for several miRNAs but often...

  • Expression of epidermal growth factor receptor in relation to BRCA1 status, basal-like markers and prognosis in breast cancer. J B Arnes // Journal of Clinical Pathology;Feb2009, Vol. 62 Issue 2, p139 

    AIMS: BRCA1-related breast cancer is associated with a basal-like phenotype, and is frequently oestrogen receptor (ER) and HER2 negative. The expression of epidermal growth factor receptor (EGFR) has been considered to be one component of the basal-like phenotype, but no standard criteria exist....

  • CCNA2 Is a Prognostic Biomarker for ER+ Breast Cancer and Tamoxifen Resistance. Gao, Tian; Han, Yong; Yu, Ling; Ao, Sheng; Li, Ziyu; Ji, Jiafu // PLoS ONE;Mar2014, Vol. 9 Issue 3, p1 

    Identification of effective prognostic biomarkers and targets are of crucial importance to the management of estrogen receptor positive (ER+) breast cancer. CCNA2 (also known as CyclinA2) belongs to the highly conserved cyclin family and is significantly overexpressed in various cancer types. In...

  • Breast cancer in young women: The effect of age on tumor biology and prognosis. Sivakumar, Poornima; Ravi, Chandni; Rodrigues, Gabriel // Clinical Cancer Investigation Journal;Mar-Apr2015, Vol. 4 Issue 2, p165 

    Background: Breast cancer (BC) is primarily a disease of older or postmenopausal women. Due to the small number of reported patients and difficulty in diagnosing BC in younger women studying this disease in this group has been challenging. Controversy exists regarding the relationship between...

  • Diffusion-Weighted Imaging in 3.0 Tesla Breast MRI: Diagnostic Performance and Tumor Characterization Using Small Subregions vs. Whole Tumor Regions of Interest. Arponent, Otso; Sudah, Mazen; Masarwah, Amro; Taina, Mikko; Rautiainen, Suvi; Könönen, Mervi; Sironen, Reijo; Kosma, Veli-Matti; Sutela, Anna; Hakumäki, Juhana; Vanninen, Ritva // PLoS ONE;10/12/2015, Vol. 10 Issue 10, p1 

    Introduction: Apparent diffusion coefficient (ADC) values are increasingly reported in breast MRI. As there is no standardized method for ADC measurements, we evaluated the effect of the size of region of interest (ROI) to diagnostic utility and correlation to prognostic markers of breast...

  • Serum biomarker 3144 m/z for prognostic detection in Chinese postmenopausal breast cancer patients. Yun Gao; ShenHua Xu; Wenming Cao; Zhanhong Chen; Xiaojia Wang; Dehong Zou // Journal of Cancer Research & Therapeutics;2015 Sepcial Issue1, Vol. 11, pC68 

    Context: Breast cancer becomes more prevalent with advancing age. The increased risk of breast cancer needs to be considered when choosing a treatment plan and a kind of detection method for the postmenopausal woman. Better breast cancer prognostication may improve selection of patients for...

  • Breast Carcinoma With Tubulopapillary Features: A Variant of Papillary Carcinoma With a Stronger Correlation With Predictors of Adverse Prognosis. Darvishian, Farbod; Konno, Fumiko; Qian, Meng; Cangiarella, Joan // International Journal of Surgical Pathology;Feb2014, Vol. 22 Issue 1, p47 

    Papillary carcinoma of the breast consists of 3 morphologically distinct established subtypes: encapsulated papillary carcinoma, solid papillary carcinoma, and invasive papillary carcinoma. Papillary carcinoma is one of the special types of breast cancer and, as such, carries a more favorable...

  • Morphological profile and receptor status in breast carcinoma: An institutional study. Rao, Chandrika; Shetty, Jayaprakash; HL, Kishan Prasad // Journal of Cancer Research & Therapeutics;Jan-Mar2013, Vol. 9 Issue 1, p44 

    Context: The data on histological and receptor status in breast cancer in an Indian population is limited as receptor status is not routinely carried out for these patients. In the present study, receptor status was analyzed and it was correlated with morphological prognostic parameters....


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics