TITLE

Recent Advances in Topoisomerase I-Targeting Agents, Camptothecin Analogues

AUTHOR(S)
Dae-Kee Kim; Namkyu Lee
PUB. DATE
December 2002
SOURCE
Mini Reviews in Medicinal Chemistry;Dec2002, Vol. 2 Issue 6, p611
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The present review concentrates on camptothecin (CPT) analogues, the most extensively studied topoisomerase I (topo I) inhibitors, and provides concise information on the structural features of human topo I enzyme, mechanisms of interaction of CPT with topo I, structure-activity relationship study of CPT analogues including the influence of lactone stability on antitumor activity, and recent updates of valuable CPT analogues.
ACCESSION #
9959074

 

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