TITLE

The sweet spot: defining virus-sialic acid interactions

AUTHOR(S)
Stencel-Baerenwald, Jennifer E.; Reiss, Kerstin; Reiter, Dirk M.; Stehle, Thilo; Dermody, Terence S.
PUB. DATE
November 2014
SOURCE
Nature Reviews Microbiology;Nov2014, Vol. 12 Issue 11, p739
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Viral infections are initiated by attachment of the virus to host cell surface receptors, including sialic acid-containing glycans. It is now possible to rapidly identify specific glycan receptors using glycan array screening, to define atomic-level structures of virus-glycan complexes and to alter the glycan-binding site to determine the function of glycan engagement in viral disease. This Review highlights general principles of virus-glycan interactions and provides specific examples of sialic acid binding by viruses with stalk-like attachment proteins, including influenza virus, reovirus, adenovirus and rotavirus. Understanding virus-glycan interactions is essential to combating viral infections and designing improved viral vectors for therapeutic applications.
ACCESSION #
99470689

 

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