Studies on mucilage from Acacia nilotica fruits as suspending agent and binding agent

Singh, Kamalpreet; Mann, Avninder; Sandhu, Bharpur; Shah, Gagan
October 2014
International Journal of PharmTech Research;Oct/Nov2014, Vol. 6 Issue 6, p1762
Academic Journal
Plant product serve as an alternative to synthetic products because of local accessibility, eco-friendly nature and lower prices compared to important synthetic products. Natural gums and mucilage have been widely explored as pharmaceutical excipients. The present study was undertaken to separate mucilage from fruits of Acacia niloticaand explore its use as Suspending agent. Mucilage extracted from the pods of Acacia niloticawere subjected to toxicity studies for its safety and preformulation studies for its suitability as a Suspending agent. Themucilage extracted is devoid of toxicity. Dispersible tablets of Paracetamolwere prepared and compared with different concentrations viz5, 10, 15, 20 and 25% ( w/w) ofAcacia nilotica mucilage powder Eight formulations were prepared and evaluated for physical parameters such as thickness, hardness, friability, weight variation, drug content, disintegration time and drug dissolution. Suspensions were prepared using different concentrations of mucilage (1, 2, 3, 4, 5 and 6%) as suspending agent. The stability of suspensions was measured using sedimentation volume (F=Hu/Ho). The suspensions prepared with Acacia niloticafruitmucilage showed better stability than tragacanth as suspending agent.


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