TITLE

Hyaluronic Acid Functionalized Porous Silica Nanoparticles for Drug Delivery and Release

AUTHOR(S)
Lingyuan Cui; Yanhui Li; Wei Zhang; Jingpeng Zhang; Qian Duan
PUB. DATE
June 2014
SOURCE
Advanced Materials Research;2014, Vol. 936, p322
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
In this paper, we reported a facile strategy to synthesize hyaluronic acid (HA) conjugated porous silica nanoparticles (pSi02) as drug carrier. The pSiC>2 were prepared by solid nano-silica nanoparticles with "surface-protected etching". Morphologies of solid and porous silica nanoparticles were characterized by SEM and TEM. Amino groups were introduced on pSiC>2 to graft HA as cancer targeting ligand. Then rifampicin used as model drug was loaded in pSiCVHA. The results indicate that pSiC>2 can perform a certain degree of slow release. Overall, the system might open the door to a new generation of carrier system for site-selective, controlled-release delivery of anticancer drugs.
ACCESSION #
99438281

 

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