TITLE

EVALUAREA PRIN METODE NONINVAZIVE A FIBROZEI HEPATICE LA PACIENÅ¢II CU COINFECÅ¢IE VHC-HIV UTILIZATORI DE DROGURI PE CALE INTRAVENOASÄ‚

AUTHOR(S)
Lazăr, Ştefan; Chiriţă, Daniel; Oprea, Cristiana; Drăghici, Loredana; Obretin, Dana; Tudor, Nicoleta; Ceauşu, Emanoil
PUB. DATE
August 2014
SOURCE
Romanian Journal of Infectious Diseases;2014, Vol. 17 Issue 3, p158
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Introduction. Coinfection of the hepatic C virus with the human immunodeficiency virus (HIV) in intravenous drug users (UDI) represents an important public health problem because of the big and increasing number of patients and the diagnostic, monitoring and treatment related challenges. Objective. To assess the hepatic fibrosis evolution within two groups of UDI patients, one having the VHCHIV coinfection and the other monoinfected with VHC. Materials and methods. Retrospective study on 109 UDI patients with chronic hepatitis C virus, out of which 70 had also HIV infection, followed-up at "Dr. Victor Babes" Clinical Hospital for Infectious and Tropical Diseases, Bucharest. The hepatic fibrosis was analysed with non-invasive methods (Fibroscan and biochemical scores). Statistical analysis was performed using SPSS Statistics v 20 as well as multi-varied statistical techniques of analysis. Results. Pacients were divided into two subgroups, one with IDU-HCV-HIV that was compared with monoinfected VHC-IDU. We studied socio-demographic characteristics stage of liver fibrosis, duration of hepatic infection, timing of HCV infection and the immunological status. Most IDU-HCV-HIV were young males with poor socio-professional status, all former or current intravenous users of drugs with new psychoactive properties. IDU-HCV-IDU had a higher liver fibrosis progression compared to UDI-HCV. Using inferential statistical analysis in patients with HCV-HIV coinfection we created a predictive algorithm of transition from the early to advanced stages of liver fibrosis. Conclusions. HCV-HIV coinfection in IDU was correlated with a more rapid progession to advanced liver fibrosis, especially in patients with immunodepression.
ACCESSION #
99437721

 

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