Advances in Treating Patients With Severe Sepsis Role of Drotrecogin Alfa (Activated)

Kleinpell, Ruth
June 2003
Critical Care Nurse;Jun2003, Vol. 23 Issue 3, p16
Academic Journal
Discusses the clinical indicators of severe sepsis and its treatment in the U.S. Effectiveness of drotrecogin alfa (activated) drug for severe sepsis cases; Statistics on mortality from severe sepsis; Pathophysiological changes associated with severe sepsis.


Related Articles

  • A Review of Articles From Last Month's Archives of Pathology & Laboratory Medicine.  // Archives of Pathology & Laboratory Medicine;Nov2009, Vol. 133 Issue 11, p1877 

    A quiz concerning clinical pathology and laboratory medicine is presented.

  • Sorting out a postal worker's headaches. McCue, Jack D.; Dionisopoulos, Paul // Cortlandt Forum;Oct98, Vol. 11 Issue 10, p204 

    Focuses on the case of a postal worker who suffered nightly headaches occurring two to three times each night. Background about the medical history of the patient; Why the headaches was classified pathophysiologically as vascular; Symptoms that are significance in diagnosing the illness;...

  • Diagnostic value of nystagmus: spontaneous and induced ocular oscillations. A Serra // Journal of Neurology, Neurosurgery & Psychiatry;Dec2002, Vol. 73 Issue 6, p615 

    Research over the past 20 years has provided a clearer understanding of the pathogenesis of most forms of nystagmus and other ocular oscillations. To the clinician, these advances translate into greater accuracy of nystagmus as a diagnostic sign. However, to capitalise on these advances, it is...

  • Eritoran: the evidence of its therapeutic potential in sepsis. Raja, Shahzad G.; Dreyfus, Gilles D. // Core Evidence;2007, Vol. 2 Issue 3, p199 

    Introduction: Sepsis and its sequelae are the leading causes of morbidity and mortality in critically ill patients. The burden to healthcare economies is also considerable. As the pathophysiology of sepsis is better defined, interventions aiming to treat sepsis are emerging. Eritoran (E5564), a...

  • Immunopathogenesis of abdominal sepsis. Weber, Georg; Swirski, Filip // Langenbeck's Archives of Surgery;Jan2014, Vol. 399 Issue 1, p1 

    Background: Sepsis is an unsolved problem worldwide, with a 30-50 % mortality rate. The recent failures of anti-TLR4, recombinant activated protein C, and anti-TNF in clinical trials indicate a need to rethink our current understanding of sepsis's pathophysiology. While the initial immune...

  • Glyceraldehyde-3-phosphate Dehydrogenase is an Inappropriate Housekeeping Gene for Normalising Gene Expression in Sepsis. Cummings, Michele; Sarveswaran, Janahan; Homer-Vanniasinkam, Shervanthi; Burke, Dermot; Orsi, Nicolas // Inflammation;Oct2014, Vol. 37 Issue 5, p1889 

    Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has long been used as a default reference gene in quantitative mRNA profiling experiments. However, its expression reportedly varies in response to a range of pathophysiological variables (inflammation, oxidative stress, hyperinsulinaemia,...

  • A rational approach to fluid therapy in sepsis. Marik, P.; Bellomo, R. // BJA: The British Journal of Anaesthesia;Mar2016, Vol. 116 Issue 3, p339 

    Aggressive fluid resuscitation to achieve a central venous pressure (CVP) greater than 8 mm Hg has been promoted as the standard of care, in the management of patients with severe sepsis and septic shock. However recent clinical trials have demonstrated that this approach does not improve the...

  • Combination Therapy with Thymosin Alpha1 and Dexamethasone Helps Mice Survive Sepsis. Xiang, Xiao-song; Li, Ning; Zhao, Yun-zhao; Li, Qiu-rong; Li, Jie-shou // Inflammation;Apr2014, Vol. 37 Issue 2, p402 

    Immune dysfunction is a major cause of mortality in septic patients. Current evidence indicates an important role for dendritic cells (DCs) in the pathophysiology of immune dysfunction, and these cells are potential targets of immunomodulation therapies. In the present study, our aim was to...

  • Sepsis: Pathogenesis, Biomarkers, and Treatment. Cheng, Baoli; Hoeft, Andreas H.; Book, Malte; Shu, Qiang; Pastores, Stephen M. // BioMed Research International;3/5/2015, Vol. 2015, p1 

    No abstract available.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics