Advances in Treating Patients With Severe Sepsis Role of Drotrecogin Alfa (Activated)
- Management challenge with drotrecogin alfa (activated). Vanscoy, Gordon J. // American Journal of Health-System Pharmacy;2/15/2002, Vol. 59 Issue 4, pS23
Clinical trial results for drotrecogin alfa (activated) are discussed in terms of potential effect on morbidity and total cost of care. Interdisciplinary collaboration is crucial for improving care in health systems; teamwork has been shown to improve outcomes in intensive care and reduce costs....
- Centoxin--birth of a budgetbuster. Taylor, David // BMJ: British Medical Journal (International Edition);5/25/91, Vol. 302 Issue 6787, p1229
Reports the launch of a pharmaceutical product for the treatment of Gram negative septicemia in Great Britain. Availability of the drug in other countries; Increase cases of Gram negative septicemia among British countries; Failure of innovative antibiotics to cure the disease prior to the...
- P & T PORTFOLIO. // Drug Topics;2/18/2002, Vol. 146 Issue 4, p16
Evaluates the recombinant form of human protein C, Drotrecogin alfa for reducing mortality in adult patients with severe sepsis. Efficacy of the drug; Pharmacology; Warnings related to use.
- gp130 receptor ligands as potential therapeutic targets for obesity. Febbraio, Mark A. // Journal of Clinical Investigation;Apr2007, Vol. 117 Issue 4, p841
Obesity and its related cluster of pathophysiologic conditions including insulin resistance, glucose intolerance, dyslipidemia, and hypertension are recognized as growing threats to world health. It is now estimated that 10% of the worldÂ’s population is overweight or obese. As a result, new...
- Chemotherapeutic targets in Plasmodia with potential for antimalarial drug discovery. Olliaro[a], Piero; Yuthavong, Yongyuth // South African Journal of Science;Jun98, Vol. 94 Issue 6, p292
Provides an overview of selected targets for antimalarial chemotherapy, with emphasis on their potential for generating effective lead compounds. Process in the digestive vacuole; Macromolecular and metabolite synthesis; Membrane processes and signaling.
- A Review of Articles From Last Month's Archives of Pathology & Laboratory Medicine. // Archives of Pathology & Laboratory Medicine;Nov2009, Vol. 133 Issue 11, p1877
A quiz concerning clinical pathology and laboratory medicine is presented.
- Sorting out a postal worker's headaches. McCue, Jack D.; Dionisopoulos, Paul // Cortlandt Forum;Oct98, Vol. 11 Issue 10, p204
Focuses on the case of a postal worker who suffered nightly headaches occurring two to three times each night. Background about the medical history of the patient; Why the headaches was classified pathophysiologically as vascular; Symptoms that are significance in diagnosing the illness;...
- Diagnostic value of nystagmus: spontaneous and induced ocular oscillations. A Serra // Journal of Neurology, Neurosurgery & Psychiatry;Dec2002, Vol. 73 Issue 6, p615
Research over the past 20 years has provided a clearer understanding of the pathogenesis of most forms of nystagmus and other ocular oscillations. To the clinician, these advances translate into greater accuracy of nystagmus as a diagnostic sign. However, to capitalise on these advances, it is...
- Optimal antimicrobial therapy for sepsis. Fish, Douglas N. // American Journal of Health-System Pharmacy;2/15/2002, Vol. 59 Issue 4, pS13
Antimicrobial selection is based on the most likely source of infection, the most common pathogens at that site, knowledge of antimicrobial susceptibility patterns in the local community and institution, and host factors. Prompt initiation of appropriate antimicrobial therapy is essential for...