Initial Screening of Children Treated With Second- Generation Antipsychotics Points to an Association Between Physical Activity and Insulin Resistance

Cote, Anita T.; Devlin, Angela M.; Panagiotopoulos, Constadina
November 2014
Pediatric Exercise Science;Nov2014, Vol. 26 Issue 4, p455
Academic Journal
Second-generation antipsychotic (SGA) medications, used to treat youth for a wide-range of mental health conditions, are associated with excessive weight gain and other comorbidities, placing these individuals at high risk for cardiovascular disease. Little is known about the effect of physical activity (PA) on cardiovascular risk in these children. Anthropometrics, fasting blood sample and self-report PA were obtained in 386 children diagnosed with mental health conditions (6–18 y). PA was classified as below (<60 min/day) or meets (≥60 min/day) current recommended guidelines for daily PA in children. SGA-treated (n = 166) and SGA-naïve (n = 220) were compared in the analysis. The SGA-treated children had higher (p < .05) BMI z-score, waist-to-height ratio, fasting glucose, and LDL-cholesterol than SGA-naïve children. Waist circumference, waist-to-height ratio, HDL cholesterol, fasting insulin, and HOMA-IR were significantly different by PA status. After adjusting for SGA-treatment duration, sex, age, and ethnicity, higher PA was associated with lower insulin resistance (HOMA-IR) in SGA-treated (mean, 95% CI; below vs. meets: 2.10 [1.84, 2.37] vs. 1.59 [1.37, 1.81], p = .046) but not in SGA-naïve (1.70 [1.47, 1.94] vs 1.55 [1.35, 1.75], p = .707) children. Upon initial screening, SGA-treated children that reported meeting the minimal recommendations for daily PA displayed lower measures of adiposity and improved insulin resistance.


Related Articles

  • Benefits of pedometer-measured habitual physical activity in healthy women. Graff, Scheila Karen; Alves, Bruna Cherubini; Toscani, Mariana Kirjner; Spritzer, Poli Mara // Applied Physiology, Nutrition & Metabolism;Feb2012, Vol. 37 Issue 1, p149 

    This cross-sectional study aimed at ( i) characterizing pedometer-determined physical activity and ( ii) examining its associations with dietary intake and anthropometric and metabolic profile in healthy women. Anthropometric and metabolic profile was evaluated in 68 healthy women of...

  • Interaction of physical activity level and metabolic syndrome among the adult Asian Indians living in Calcutta, India. Das, M.; Pal, S.; Ghosh, Arnab // Journal of Nutrition, Health & Aging;Jun2012, Vol. 16 Issue 6, p539 

    Objectives: The present community-based cross-sectional study was aimed to study the interaction of physical activity level (PAL) and metabolic syndrome (MS) among the adult Asian Indians. Methods: A total of 448 adult (> 30 years) individuals (males and females) inhabiting in and around...

  • Serum Adiponectin Concentrations in Relation to Lipid Profile, Anthropometric Variables and Insulin Resistance in Patients with Metabolic Syndrome. Mirinazhad, Mir-Mousa; Farhangi, Mahdieh Abbasalizad; Jahangiri, Leila; Yaghoubi, Alireza // Malaysian Journal of Nutrition;2014, Vol. 20 Issue 3, p283 

    Introduction: Associations between serum adiponectin concentrations and anthropometric and metabolic parameters in obesity and diabetes have been elucidated; however, the relationship between serum adiponectin and cardiovascular risks in patients with metabolic syndrome are less studied....

  • Iron status and cardiovascular disease risk in black South African women: the PURE study. Aderibigbe, O. R.; Pisa, P. T.; Mamabolo, R. L.; Kruger, H. S.; Vorster, H. H.; Kruger, A. // South African Journal of Clinical Nutrition;2011, Vol. 24 Issue 4, p179 

    Objective: To examine the associations between measures of iron status and cardiovascular disease (CVD) risk factors in South African women. Method: In a cross-sectional study, demographic information and health history were obtained during individual interviews using validated questionnaires in...

  • BMI Change, Fitness Change and Cardiometabolic Risk Factors Among 8th Grade Youth. Jago, Russell; Drews, Kimberly L.; McMurray, Robert G.; Baranowski, Tom; Galassetti, Pietro; Foster, Gary D.; Moe, Ester; Buse, John B. // Pediatric Exercise Science;Feb2013, Vol. 25 Issue 1, p52 

    This paper examined whether a two-year change in fitness, body mass index (BMI) or the additive effect of change in fitness and BMI were associated with change in cardiometabolic risk factors among youth. Cardiometabolic risk factors, BMI group (normal weight, overweight or obese) were obtained...

  • The Relationship Between Physical Activity and the Metabolic Syndrome Score in Children. DuBose, Katrina D.; McKune, Andrew J.; Brophy, Patricia; Geyer, Gabriel; Hickner, Robert C. // Pediatric Exercise Science;Aug2015, Vol. 27 Issue 3, p364 

    The relationship between physical activity levels and the metabolic syndrome (MetSyn) score was examined in 72 boys and girls (9.5 ± 1.2 years). A fasting blood draw was obtained; waist circumference and blood pressure measured, and an accelerometer was worn for 5 days. Established cut points...

  • Waist:height ratio, waist circumference and metabolic syndrome abnormalities in Colombian schooled adolescents: a multivariate analysis considering located adiposity. Agredo-Zúñiga, Ricardo Antonio; Aguilar-de Plata, Cecilia; Suárez-Ortegón, Milton Fabian // British Journal of Nutrition;9/14/2015, Vol. 114 Issue 5, p700 

    Very few large studies in Latin America have evaluated the association between waist:height ratio (W-HtR) and cardiometabolic risk in children and adolescents. Further, multivariable analyses verifying the independence of located subcutaneous fat have not been conducted so far. The aim of this...

  • Anthropometric indicators associated with hypertriglyceridemia in the prediction of visceral fat. Cunha de Oliveira, Carolina; Carneiro Roriz, Anna Karla; de Almeida Moreira, Pricilla; Eickemberg, Michaela; Reis Amaral, Magali Teresopolis; Santana Passos, Luiz Carlos; Barbosa Ramos, Lílian // Brazilian Journal of Kineanthropometry & Human Performance;2014, Vol. 16 Issue 5, p485 

    The accumulation of visceral fat is strongly associated with cardiometabolic changes. Alternative methods, such as the association between anthropometric indicators and hypertriglyceridemia, are used as the best estimate for the accumulation of visceral fat, preventing cardiovascular diseases....

  • The Relationship Between Objectively Measured Physical Activity, Salivary Cortisol, and the Metabolic Syndrome Score in Girls. DuBose, Katrina D.; McKune, Andrew J. // Pediatric Exercise Science;Aug2014, Vol. 26 Issue 3, p221 

    The relationship between physical activity levels, salivary cortisol, and the metabolic syndrome (MetSyn) score was examined. Twenty-three girls (8.4 ± 0.9 years) had a fasting blood draw, waist circumference and blood pressure measured, and wore an ActiGraph accelerometer for 5 days. Saliva...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics