TITLE

Association study of miR-149 rs2292832 and miR-608 rs4919510 and the risk of hepatocellular carcinoma in a large-scale population

AUTHOR(S)
RUI WANG; JUN ZHANG; YANYUN MA; LINQI CHEN; SHICHENG GUO; XIAOJIAO ZHANG; YUNFANG MA; LIJUN WU; XIAOYU PEI; SIRAN LIU; JIUCUN WANG; HEPING HU; JIE LIU
PUB. DATE
November 2014
SOURCE
Molecular Medicine Reports;2014, Vol. 10 Issue 5, p2736
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Polymorphisms in pre-microRNAs (miRNAs) or mature miRNAs may influence miRNA processing or target binding, thus contributing to tumorigenesis and cancer development. The present study aimed to evaluate whether miR-149 rs2292832 (C>T) and miR-608 rs4919510 (G>C) are associated with the risk and clinical characteristics of hepatocellular carcinoma (HCC) in a large-scale population. miR-149 rs2292832 and miR-608 rs4919510 were genotyped in a total of 993 patients with HCC and 992 unrelated healthy subjects by Sequenom MassARRAY. The results showed that, compared with the reference CC genotype, the TC+TT genotype of miR-149 was more highly associated with HCC [CC vs. TC+TT: Odds ratio (OR)=1.384, 95% confidence interval (CI)=1.013-1.892, P=0.041], and was also associated with an increased risk of hepatitis B virus (HBV)-associated HCC (CC vs. TC+TT: OR=1.453, 95% CI=1.034-2.042, P=0.031). However, no significant association between miRNA-608 rs4919510 and the risk of HCC/HBV-associated HCC was found. In addition, these two SNPs were shown not to be correlated with a range of clinical characteristics. The present study may provide an indicator for identification of the high risk of HCC in patients.
ACCESSION #
99268240

 

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