TITLE

Analysis of Clinicopathological Features and Prognosis of Gastric Carcinoma with Neuroendocrine Differentiation and Mixed Gonadal Neuroendocrine Carcinoma of the Stomach

AUTHOR(S)
SONG Wei; YU Qingkai
PUB. DATE
August 2014
SOURCE
Tianjin Medical Journal;Aug2014, Vol. 42 Issue 8, p799
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective To investigate the clinical pathological features and prognosis of gastric carcinoma with neuroendocrine differentiation (NED) and mixed gonadal neuroendocrine carcinoma of the stomach (MANECs). Methods A retrospective analysis of 61 cases of gastric carcinoma with NED and 34 cases of MANECs and their histochemistry and immunohistochemistry were also observed. Prognosis of the 2 groups were compared by the Kaplan-Meiers survival analysis. Prognostic factors associated with patients with gastric cancer were analyzed by COX proportional hazards model. Results Tumor location, distant metastasis and lymph node metastasis were statistically different between these 2 groups (P < 0.05). Syn positive expression rate is higher than CgA and CD56 in the gastric carcinoma with NED group; Postoperative survive period of the gastric carcinoma with NED is shorter than that of MANECs (P < 0.05). Lymph node metastasis and distant regional transfer is obviously correlated with prognosis (P < 0.05). Conclusion Immunohistochemistry is important for the diagnosis of these two tumor. The number of neuroendocrine cells can help to assess prognosis and guide treatment.
ACCESSION #
99221204

 

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