TITLE

A Review of the Role of Sphingosine-1-Phosphate in the Brain: An Important Mediator Implicated in the Central Nervous System

AUTHOR(S)
PUNSAWAD, Chuchard
PUB. DATE
December 2014
SOURCE
Walailak Journal of Science & Technology;2014, Vol. 11 Issue 5-8, p395
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Sphingosine-1-phosphate (SIP) is a bioactive lipid that signals through a family of G proteincoupled receptors, consisting of 5 members, termed SI PI, S1P2, S1P3, S1P4 and S1P5. Activation of SIP results in the regulation of several cellular functions, including cell proliferation, process retraction, cell survival and migration. Deregulation of SIP receptor expression and/or the SIP signaling pathway may play an important role in the development in the treatment of neurological disorders. The aim of the present review is to summarize the SIP signaling pathway and SIP receptor expression in the cellular components of human and rodent brains. The published information will be helpful to delineate the important mechanisms in the development of neurological disorders such as Alzheimer's disease, multiple sclerosis, and traumatic brain injury, and serve as a guideline for the designing of further studies investigating SIP involvement in the brain.
ACCESSION #
99179356

 

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