Extrapontine Myelinolysis in an 18-Month-Old Boy With Diabetic Ketoacidosis: Case Report and Literature Review

Gencpinar, Pinar; Duman, Ozgur; Tekguc, Hakan; Senol, A. Utku; Dursun, Oguz
November 2014
Journal of Child Neurology;Nov2014, Vol. 29 Issue 11, p1548
Academic Journal
Extrapontine myelinolysis is characterized by symmetric demyelination following rapid shifts in serum osmolality in the supratentorial compartment. Extrapontine myelinolysis in children is rare compared to adults. The most common underlying pathophysiology is rapid correction of hyponatremia. Only 2 cases were published after diabetic ketoacidosis without electrolyte imbalance in the English literature. This study presents an unusual and possibly the youngest case of extrapontine myelinolysis that occurred in the setting of diabetic ketoacidosis and complicated cerebral edema without electrolyte imbalance, along with a review of the literature.


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