Clinical Characteristics and Adequate Treatment of Familial Adenomatous Polyposis Combined with Desmoid Tumors

Won Beom Jung; Chan Wook Kim; Jin Cheon Kim
October 2014
Cancer Research & Treatment;2014, Vol. 46 Issue 4, p366
Academic Journal
Purpose The objective of this study was to examine the clincopathologic characteristics and outcomes of familial adenomatous polyposis (FAP) patients with and without desmoid tumors (DTs), including the risk factors for progression of FAP-related DTs. Materials and Methods We reviewed the medical records and database of all patients with FAP who were treated between January 1993 and December 2011. Results Of 75 FAP patients, 18 (24%) were FAP with DTs. Seventeen of these had intra-abdominal DTs and one had intra- and extra-abdominal DTs. We divided the patients into two groups according to type of resection; the R0 or R1 resection group, referred to as the curative resection group (eight patients), and the R2 resection/palliative operation/medical treatment group, referred to as the palliative resection group (10 patients). Two patients in the curative resection group and two patients in the palliative group had progressed to tumor growth by the follow-up (p=0.800). In univariate analysis, DT diagnosis before or simultaneously with FAP diagnosis (DTs unrelated to surgical trauma) was a significant risk factor for tumor progression at final follow-up. Conclusion A multidisciplinary approach to DT treatment is needed, including nonsteroidal antiinflammatory drugs, anti-estrogens, cytotoxic agents, and surgery. However, the role of surgery in resectable and complicated tumors may be limited. DT unrelated to surgical trauma has a relatively poor prognosis.


Related Articles

  • An international randomised trial of celecoxib versus celecoxib plus difluoromethylornithine in patients with familial adenomatous polyposis. Lynch, Patrick M.; Burke, Carol A.; Phillips, Robin; Morris, Jeffrey S.; Slack, Rebecca; Xuemei Wang; Jun Liu; Patterson, Sherri; Sinicrope, Frank A.; Rodriguez-Bigas, Miguel A.; Half, Elizabeth; Bulow, Steffen; Latchford, Andrew; Clark, Sue; Ross, William A.; Malone, Bonnie; Hasson, Hennie; Richmond, Ellen; Hawk, Ernest // Gut;Feb2016, Vol. 65 Issue 2, p286 

    Background and aim Although Non-steroidal anti-inflammatory drugs reduce colorectal adenoma burden in familial adenomatous polyposis (FAP), the utility of combining chemopreventive agents in FAP is not known. We conducted a randomised trial of celecoxib (CXB) versus CXB+diflouromethylornithine...

  • New NSAID warnings. Levin, Arthur A. // HealthFacts;Feb96, Vol. 21 Issue 201, p2 

    Reports that the Food and Drug Administration has issued warning for the Nonsteroidal anti-inflammatory drugs (NSAID). Reasons for warning; People who are likely to be affected by NSAIDs.

  • Drugs for Aches And Pains May Also Help Slow the Progress of Alzheimer's Disease.  // Tufts University Health & Nutrition Letter;Sep2000, Vol. 18 Issue 7, p1 

    Reports that researchers are giving serious consideration to the possibility that nonsteroidal anti-inflammatory drugs (NSAID) such as ibuprofen and naproxen may also play a role in slowing or even preventing Alzheimer's disease. Evidence that NSAIDs may help with Alzheimer's; Response of the...

  • NSAIDs may protect against Alzheimer's disease.  // Patient Care;1/30/2002, Vol. 36 Issue 2, p8 

    Focuses on a study conducted by a Dutch team concerning the possible neuroprotective role that non-steroidal anti-inflammatory agents (NSAID) might play in preventing Alzheimer's disease. Subjects of the study; Methodology; Results of the study.

  • NSAIDs improve quality of sleep in patients with osteoarthritis pain.  // Geriatrics;Jan98, Vol. 53 Issue 1, p70 

    Presents information on nonsteroidal anti-inflammatory agents (NSAID) relative to the promotion of sleep in patients with osteoarthritis pain. Details on a study conducted by researcher Angeline Carlson, PhD, from Data Intelligence, a consulting firm in Eden Praire, Montana; Findings of the...

  • NSAIDs critical to the treatment, prevention of CME. Heier, Jeffrey S. // Ophthalmology Times;02/01/2001, Vol. 26 Issue 3, p36 

    Highlights the use of non-steroidal anti-inflammatory drugs for the treatment of cystoid mascular edema (CME) and related loss of visual acuity. Symptoms of CME in patients; Causes of CME; Signs of CME in patients with complicated cataract surgery.

  • Q: Do any NSAIDs besides piroxicam suppress the growth of some cancers in dogs?  // Veterinary Medicine;May2009, Vol. 104 Issue 5, p226 

    The article provides an answer to a question concerning the effectiveness of nonsteroidal anti-inflammatory drugs (NSAIDs) in treating postsurgical pain and osteoarthritis in dogs.

  • Anti-inflammatory drugs may protect against Alzheimer's disease.  // Executive Health's Good Health Report;Dec96, Vol. 33 Issue 3, p8 

    Discusses a University of British Columbia research summary data indicating the possibility that nonsteroidal anti-inflammatory agents have a protective effect against Alzheimer's disease.

  • Research suggests certain drugs can cut risk of melanoma.  // Cancer Nursing Practice;Jun2012, Vol. 11 Issue 5, p4 

    The article reports a study by researchers in Denmark, which revealed that risk of developing squamous cell carcinoma (SCC) fell by 15 per cent and malignant melanoma fell by 13 per cent, in people on more than two prescriptions for non-steroidal anti-inflammatory drugs (NSAIDs).


Other Topics