TITLE

Clinical Usefulness of Hydromorphone-OROS in Improving Sleep Disturbances in Korean Cancer Patients: A Multicenter, Prospective, Open-Label Study

AUTHOR(S)
Seong Hoon Shin; Ho Sup Lee; Yang Soo Kim; Young Jin Choi; Sung Hyun Kim; Hyuk Chan Kwon; Sung Yong Oh; Jung Hun Kang; Chang Hak Sohn; Sang Min Lee; Jin Ho Baek; Young Joo Min; Choongrak Kim; Joo Seop Chung
PUB. DATE
October 2014
SOURCE
Cancer Research & Treatment;2014, Vol. 46 Issue 4, p331
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Purpose To evaluate the efficacy of hydromorphone-OROS (HM-OROS) in reducing sleep disturbance and relieving cancer pain. Materials and Methods One hundred twenty cancer patients with pain (numeric rating scale [NRS] = 4) and sleep disturbance (NRS = 4) were evaluated. The initial HM-OROS dosing was based on previous opioid dose (HM-OROS:oral morphine=1:5). Dose adjustment of the study drug was permitted at the investigator's discretion. Pain intensity, number of breakthrough pain episodes, and quality of sleep were evaluated. Results A total of 120 patients received at least one dose of HM-OROS; 74 of them completed the final assessment. Compared to the previous opioids, HM-OROS reduced the average pain NRS from 5.3 to 4.1 (p < 0.01), worst pain NRS from 6.7 to 5.4 (p < 0.01), sleep disturbance NRS from 5.9 to 4.1 (p < 0.01), incidence of breakthrough pain at night from 2.63 to 1.53 times (p < 0.001), and immediate-release opioids use for the management of breakthrough pain from 0.83 to 0.39 times per night (p = 0.001). Of the 74 patients who completed the treatment, 83.7% indicated that they preferred HM-OROS to the previous medication. The adverse events (AEs) were somnolence, asthenia, constipation, dizziness, and nausea. Conclusion HM-OROS was efficacious in reducing cancer pain and associated sleep disturbances. The AEs were manageable.
ACCESSION #
98855009

 

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