TITLE

MELAMINE-INDUCED NEPHROTOXICITY IN WEANED PIGLETS IN SERBIA

AUTHOR(S)
Kureljušić, Branislav; Ivetić, Vojin; Savić, Božidar; Kureljušić, Jasna; Jezdimirović, Nemanja; Cvetojević, Ɖorđe; Moračanin, Slavica Vesković; Stefanović, Srđan; Juntes, Polona; Jakić-Dimić, Dobrila
PUB. DATE
September 2014
SOURCE
Slovenian Veterinary Research;2014, Vol. 51 Issue 3, p141
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Melamine is not approved for use in animal feed, although evidence of melamine poisoning in pigs has been found. Melamine in animal feed can induce nephrolithiasis, chronic kidney inflammation, bladdercarcinoma and even death in animals. In September 2011, nine hundred 40-60-day-old piglets from a commercial finishing farm in Serbia developed anorexia, wasting, polydipsia and lethargy. At necropsy, the main macroscopic finding in ten necropsied piglets was observed on the kidneys. The kidneys were slightly enlarged and firm in consistency. The cortical surface was wrinkled, with a diffuse distribution of the yellow foci in thecortexand medulla. Microscopically, theseyellowfociwereaccumulationsof crystals located predominantly withinthe lumina of the dilated distal straight and convoluted tubules and collecting ducts. The crystals appeared variable and birefringent when viewed under polarized light. Two types of crystals were observed: the first type had several dark striations radiating from the eosinophilic round centre, while the second type consisted of pale green to brown irregular striated aggregates without an eosinophilic centre. In all cases, multifocally, there were moderate aggregates of lymphocytes, plasma cells, macrophages and multinucleated giant cells within the interstitium. From the clinical signs, necropsy findings, histochemicai and toxicological results, it was concluded that melaminecontaminated feed was the primary cause of nephrotoxicity and death in the observed piglets. To our knowledge, this is the first report of melamine poisoning in pigs in Serbia.
ACCESSION #
98776824

 

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