A gene-expression profile independently predicted disease outcome in young women with breast cancer

van de Vijver, M.J.; He, Y.D.; van't Veer, L.J.; Hillner, Bruce E.
May 2003
ACP Journal Club;May/Jun2003, Vol. 138 Issue 3, p82
Academic Journal
Summarizes a study that examined the prognostic value of a gene-expression profile for predicting disease outcome in young women with breast cancer. Characterization of the patients; Description of the prediction guide; Main results of the study.


Related Articles

  • Gene expression of PMP22 is an independent prognostic factor for disease-free and overall survival in breast cancer patients. Dan Tong; Heinze, Georg; Pils, Dietmar; Wolf, Andrea; Singer, Christian F.; Concin, Nicole; Hofstetter, Gerda; Schiebel, Ingrid; Rudas, Margaretha; Zeillinger, Robert // BMC Cancer;2010, Vol. 10, p682 

    Background: Gene expression of peripheral myelin protein 22 (PMP22) and the epithelial membrane proteins (EMPs) was found to be differentially expressed in invasive and non-invasive breast cell lines in a previous study. We want to evaluate the prognostic impact of the expression of these genes...

  • Gene expression and cancer: getting it together.  // Nature Genetics;May2002, Vol. 31 Issue 1, p1 

    Editorial. Comments on the article published in The New York Times 'Telling Threatening Tumors from Harmless Ones.' Reference to a study linking genome-wide expression profiles of breast cancer samples to clinical outcome; Superiority of molecular classification schemes to histopathological...

  • P21[sup WAF1] expression in invasive breast cancer and its association with p53, AP-2, cell proliferation, and prognosis. Pellikainen, M.J.; Pekola, T.T.; Ropponen, K.M.; Kataja, V.V.; Kellokoski, J.K.; Eskelinen, M.J.; Kosma, V.-M. // Journal of Clinical Pathology;Mar2003, Vol. 56 Issue 3, p214 

    Aims: To evaluate the expression and prognostic relevance of p21[sub WAF1] in breast cancer and to investigate its association with p53, activator protein 2 (AP-2), and cell proliferation (as assessed by Ki-67 expression). Methods: p21[sup WAF1] expression was analysed immunohistochemicolly in a...

  • DETECCION INMUNOHISTOQUIMICA DE LA EXPRESSION DE LA ONCOPROTEINA c-erbB-2 EN TUMORES DUCTALES Y LOBULILLARES DE MAMA. Rodriguez, Héctor; Needham, Douglas; González, Raúl; Araya, Juan Carlos // Revista Chilena de Tecnología Médica;2012, Vol. 32 Issue 1, p1671 

    Breast cancer is one of the major diseases in women and devote great economic and scientific efforts. The intention of continuing to find ways of better and early diagnosis, and improved prognosis. In the age ranges of increased risk for this disease have been described several triggers such as...

  • Functional pathway characterized by gene expression analysis of supraclavicular lymph node metastasis-positive breast cancer. Oishi, Yoko; Nagasaki, Koichi; Miyata, Satoshi; Matsuura, Masaaki; Nishimura, Sei-ichiro; Akiyama, Futoshi; Iwai, Takehisa; Miki, Yoshio // Journal of Human Genetics;Mar2007, Vol. 52 Issue 3, p271 

    The outcome of breast cancer patients with supraclavicular lymph node metastasis is generally poor, but some patients do survive for a long time. Consequently, the ability to predict the outcome is important in terms of choosing the appropriate therapy for breast cancer patients with...

  • In this issue.  // Annals of Oncology;Oct2010, Vol. 21 Issue 10, p1929 

    No abstract available.

  • Identification of aberrant chromosomal regions from gene expression microarray studies applied to human breast cancer. Andreas Buness; Ruprecht Kuner; Markus Ruschhaupt; Annemarie Poustka; Holger Sültmann; Achim Tresch // Bioinformatics;Sep2007, Vol. 23 Issue 17, p2273 

    Motivation: In cancer, chromosomal imbalances like amplifications and deletions, or changes in epigenetic mechanisms like DNA methylation influence the transcriptional activity. These alterations are often not limited to a single gene but affect several genes of the genomic region and may be...

  • Evidence of epigenetic changes affecting the chromatin state of the retinoic acid receptor β2 promoter in breast cancer cells. Sirchia, Silvia M; Ferguson, Anne T; Sironi, Elena; Subramanyan, Smitha; Orlandi, Rosaria; Sukumar, Saraswati; Sacchi, Nicoletta // Oncogene;3/16/2000, Vol. 19 Issue 12, p1556 

    Retinoic acid (RA)-resistance in breast cancer cells has been associated with irreversible loss of retinoic acid receptor β, RARβ, gene expression. Search of the causes affecting RARβ gene activity has been oriented at identifying possible differences either at the level of one of the...

  • A comparison of gene expression signatures from breast tumors and breast tissue derived cell lines. Ross, Douglas T.; Perou, Charles M. // Disease Markers;2001, Vol. 17 Issue 2, p99 

    Cell lines derived from human tumors have historically served as the primary experimental model system for exploration of tumor cell biology and pharmacology. Cell line studies, however, must be interpreted in the context of artifacts introduced by selection and establishment of cell lines in...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics