Type C-chronic hepatitis patients who had autoimmune phenomenon and developed jaundice during interferon therapy

Sezaki, Hitomi; Arase, Yasuji; Tsubota, Akihito; Suzuki, Yoshiyuki; Kobayashi, Masahiro; Saitoh, Satoshi; Suzuki, Fumitaka; Akuta, Norio; Someya, Takashi; Ikeda, Kenji; Kumada, Hiromitsu
May 2003
Journal of Gastroenterology;2003, Vol. 38 Issue 5, p493
Academic Journal
Of a total of 2342 patients with type-C chronic hepatitis treated with interferon (IFN) at this hospital, 3 patients developed jaundice during the course of IFN therapy, but all 3 of them exhibited negative conversion of hepatitis C virus (HCV)-RNA following readministration of IFN. All 3 patients were assessed as having "probable autoimmune hepatitis (AIH)" in accordance with the AIH scoring system, indicating association with an "autoimmune phenomenon". Readministration of IFN at a low-dose induced activation of the autoimmune phenomenon, leading to fulminant hepatocellular impairment. As a result, HCV-RNA content dropped dramatically, possibly contributing to the negative conversion of HCV-RNA noted following the readministration of IFN. At present, no adequate therapy has been established for type-C chronic hepatitis with autoimmune manifestations. However, in conclusion, our findings suggested that: IFN should be a frontline regiment: (1) if autoantibody titers are low or patients are rated as having "probable AIH" or lower in accordance with the AIH scoring system, indicating a strong link to chronic hepatitis or (2) if IFN is expected to be efficacious on the basis of genotype of HCV-RNA level; even if there is acute exacerbation of type-C chronic hepatitis, IFN should be re-adminsitered in the HCV-RNA level has dropped subsequently.


Related Articles

  • Hepatitis C Virus Infection: Immune Responsiveness and Interferon-a Treatment. Jirillo, E.; Pellegrino, N.M.; Piazzolla, G.; Caccavo, D.; Antonaci, S. // Current Pharmaceutical Design;Jan2000, Vol. 6 Issue 2, p169 

    Hepatitis C virus (HCV) is responsible for most cases of posttransfusion hepatitis and sporadic or community-acquired non-A, non-B hepatitis. Different generations of enzyme-linked immunosorbent assay have been generated for detecting antibodies to HCV epitopes. HCV-RNA quantitative analysis has...

  • Peginterferon-α.  // Reactions Weekly;3/12/2011, Issue 1342, p26 

    The article describes the case of a 67-year-old woman who developed sarcoid-related dacryoadenitis following treatment for hepatitis C virus infection, which peginterferon-α.

  • In Vivo and In Vitro Induction of MxA Protein in Peripheral Blood Mononuclear Cells from Patients Chronically Infected with Hepatitis C Virus. Fernandez, Mario; Quiroga, Juan Antonio; Martin, Julio; Herrero, Monserrat; Pardo, Margarita; Horisberger, Michel Andre; Carreno, Vicente // Journal of Infectious Diseases;8/1/99, Vol. 180 Issue 2 

    Examines the induction of MxA protein in peripheral blood mononuclear cells in patients infected with hepatitis C virus. Activation of interferon system to viral infection; Use of immunoblot assay in the detection of human MxA protein; Differences in the immunoregulatory mechanisms between...

  • Differential Effect of Interferon on Hepatitis C Virus lb Quasispecies in the Nonstructural Protein 5A Gene. Sakuma, Ikuo; Kurosaki, Masayuki; Izumi, Namiki; Marumo, Fumiaki; Sato, Chifumi // Journal of Infectious Diseases;10/1/99, Vol. 180 Issue 4, p1001 

    Investigates the close correlation between amino acid mutations in the nonstructural protein 5 of hepatitis C virus (HCV) in response to interferon therapy. Dynamic change of sensitivity region quasispecies; Absence of mutant-type quasispecies detected after therapy.

  • ATL>Changes in serum levels of hepatitis C virus genotype 1b monitored by real-time quantitative polymerase chain reaction as a predictor of long term response to interferon-α treatment. Enomoto, Masaru; Nishiguchi, Shuhei; Shiomi, Susumu; Tanaka, Motoharu; Yokogawa, Tadashi; Fukuda, Katsuhiko; Ueda, Tadashi; Tamori, Akihiro; Habu, Daiki; Takeda, Tadashi; Yano, Yoshihisa; Otani, Shuzo // American Journal of Gastroenterology;Feb2002, Vol. 97 Issue 2, p420 

    OBJECTIVE:The aim of this study was to find whether there is a relationship between the changes in the amounts of hepatitis C virus (HCV) at the start of interferon treatment and the long term response to therapy.METHODS:In 20 patients with HCV genotype 1b each given 880 MU of interferon-α,...

  • Chronic Infection with Hepatitis C Virus in Patients with Elevated or Persistently Normal Serum Alanine Aminotransferase Levels: Comparison of Hepatic Histology and Response to Interferon Therapy. Shiffman, Mitchell L.; Stewart, Charmaine A.; Hofmann, Charlotte M.; Contos, Melissa J.; Luketic, Velimir A.; Sterling, Richard K.; Sanyal, Arun J. // Journal of Infectious Diseases;12/1/2000, Vol. 182 Issue 6 

    Ninety-five patients with chronic hepatitis C virus (HCV) infection, 35 with persistently normal serum alanine aminotransferase (ALT) levels, were randomized to treatment with daily interferon (IFN) for 3 months, followed by IFN 3 times weekly (TIW) for 12 months (group A) or TIW for 18 months...

  • Infection with hepatitis C virus genotype 4 is associated with a poor response to interferon-alpha. Sherman, Morris; Marinos, George; Sedarati, Farhad; Sherman, M; Marinos, G; Sedarati, F // Annals of Internal Medicine;11/20/2001, Vol. 135 Issue 10, p927 

    Focuses on the response of patients infected with hepatitis C virus genotype 4 to interferon-alpha. Improvement in the initial and sustained virologic response during and after treatment with peginterferon-aplha2a; Normalization of the serum alanine aminotransferase concentrations; Increase of...

  • Treatment of hepatitis C virus in elderly persons with interferon... Van Thiel, David H.; Friedlander, Lois // Journals of Gerontology Series A: Biological Sciences & Medical ;Nov95, Vol. 50A Issue 6, pM330 

    Presents the results of a study on the treatment of hepatitis C virus (HCV) in elderly persons. Prevalence of HCV among adults; Interferon ... (IFN) as the only therapy which has been approved by the Food and Drug Administration for HCV treatment; Evidence to show that elderly individuals can...

  • Persistence Rate and Progression of Vertically Acquired Hepatitis C Infection. Tovo, Pier-Angelo; Pembrey, Lucy Jane; Newell, Marie-Louise // Journal of Infectious Diseases;2/1/2000, Vol. 181 Issue 2, p419 

    Describes the natural history of perinatal hepatitis C virus (HCV) infection. Use of interferon in the standard treatment for adults with chronic hepatitis C; Mother-to-child transmission of HCV; Establishment of the European Pediatric Hepatitis C Virus Infection Network to elucidate issues...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics